Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518531056> ?p ?o ?g. }
- W2518531056 endingPage "e1002553" @default.
- W2518531056 startingPage "e1002553" @default.
- W2518531056 abstract "The differential programming of sperm and eggs in gonads is a fundamental topic in reproductive biology. Although the sexual fate of germ cells is believed to be determined by signaling factors from sexually differentiated somatic cells in fetal gonads, the molecular mechanism that determines germ cell fate is poorly understood. Herein, we show that mothers against decapentaplegic homolog 4 (SMAD4) in germ cells is required for female-type differentiation. Germ cells in Smad4-deficient ovaries respond to retinoic acid signaling but fail to undergo meiotic prophase I, which coincides with the weaker expression of genes required for follicular formation, indicating that SMAD4 signaling is essential for oocyte differentiation and meiotic progression. Intriguingly, germline-specific deletion of Smad4 in Stra8-null female germ cells resulted in the up-regulation of genes required for male gonocyte differentiation, including Nanos2 and PLZF, suggesting the initiation of male-type differentiation in ovaries. Moreover, our transcriptome analyses of mutant ovaries revealed that the sex change phenotype is achieved without global gene expression changes in somatic cells. Our results demonstrate that SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells." @default.
- W2518531056 created "2016-09-16" @default.
- W2518531056 creator A5015016528 @default.
- W2518531056 creator A5021288610 @default.
- W2518531056 creator A5026875120 @default.
- W2518531056 creator A5050911555 @default.
- W2518531056 creator A5057633071 @default.
- W2518531056 creator A5085658022 @default.
- W2518531056 date "2016-09-08" @default.
- W2518531056 modified "2023-10-03" @default.
- W2518531056 title "Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming" @default.
- W2518531056 cites W1606401780 @default.
- W2518531056 cites W1629512138 @default.
- W2518531056 cites W1768274470 @default.
- W2518531056 cites W1923939500 @default.
- W2518531056 cites W1977825177 @default.
- W2518531056 cites W1979106724 @default.
- W2518531056 cites W1979291624 @default.
- W2518531056 cites W1980666758 @default.
- W2518531056 cites W1983710378 @default.
- W2518531056 cites W1989357942 @default.
- W2518531056 cites W1995391294 @default.
- W2518531056 cites W1996394696 @default.
- W2518531056 cites W1997444723 @default.
- W2518531056 cites W2000113246 @default.
- W2518531056 cites W2002095336 @default.
- W2518531056 cites W2004609419 @default.
- W2518531056 cites W2007018695 @default.
- W2518531056 cites W2008009288 @default.
- W2518531056 cites W2009065414 @default.
- W2518531056 cites W2013554143 @default.
- W2518531056 cites W2034661247 @default.
- W2518531056 cites W2036654302 @default.
- W2518531056 cites W2037437212 @default.
- W2518531056 cites W2042921786 @default.
- W2518531056 cites W2047586438 @default.
- W2518531056 cites W2049424035 @default.
- W2518531056 cites W2050518767 @default.
- W2518531056 cites W2051808379 @default.
- W2518531056 cites W2055994125 @default.
- W2518531056 cites W2063995187 @default.
- W2518531056 cites W2066293255 @default.
- W2518531056 cites W2069829573 @default.
- W2518531056 cites W2077053535 @default.
- W2518531056 cites W2078638321 @default.
- W2518531056 cites W2080722280 @default.
- W2518531056 cites W2081087045 @default.
- W2518531056 cites W2083460129 @default.
- W2518531056 cites W2087643679 @default.
- W2518531056 cites W2093046312 @default.
- W2518531056 cites W2096196036 @default.
- W2518531056 cites W2098590189 @default.
- W2518531056 cites W2103511872 @default.
- W2518531056 cites W2106958660 @default.
- W2518531056 cites W2116989098 @default.
- W2518531056 cites W2117144912 @default.
- W2518531056 cites W2121166984 @default.
- W2518531056 cites W2121629312 @default.
- W2518531056 cites W2130845462 @default.
- W2518531056 cites W2134537052 @default.
- W2518531056 cites W2136691417 @default.
- W2518531056 cites W2140159026 @default.
- W2518531056 cites W2141093419 @default.
- W2518531056 cites W2143526409 @default.
- W2518531056 cites W2149945210 @default.
- W2518531056 cites W2157259126 @default.
- W2518531056 cites W2158120612 @default.
- W2518531056 cites W2158737623 @default.
- W2518531056 cites W2162780161 @default.
- W2518531056 cites W2215595807 @default.
- W2518531056 cites W2281478543 @default.
- W2518531056 cites W2328212469 @default.
- W2518531056 cites W4296588288 @default.
- W2518531056 doi "https://doi.org/10.1371/journal.pbio.1002553" @default.
- W2518531056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5015973" @default.
- W2518531056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27606421" @default.
- W2518531056 hasPublicationYear "2016" @default.
- W2518531056 type Work @default.
- W2518531056 sameAs 2518531056 @default.
- W2518531056 citedByCount "21" @default.
- W2518531056 countsByYear W25185310562017 @default.
- W2518531056 countsByYear W25185310562019 @default.
- W2518531056 countsByYear W25185310562020 @default.
- W2518531056 countsByYear W25185310562021 @default.
- W2518531056 countsByYear W25185310562022 @default.
- W2518531056 countsByYear W25185310562023 @default.
- W2518531056 crossrefType "journal-article" @default.
- W2518531056 hasAuthorship W2518531056A5015016528 @default.
- W2518531056 hasAuthorship W2518531056A5021288610 @default.
- W2518531056 hasAuthorship W2518531056A5026875120 @default.
- W2518531056 hasAuthorship W2518531056A5050911555 @default.
- W2518531056 hasAuthorship W2518531056A5057633071 @default.
- W2518531056 hasAuthorship W2518531056A5085658022 @default.
- W2518531056 hasBestOaLocation W25185310561 @default.
- W2518531056 hasConcept C104317684 @default.
- W2518531056 hasConcept C109825262 @default.
- W2518531056 hasConcept C134305767 @default.
- W2518531056 hasConcept C148738053 @default.