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- W2518532009 abstract "Examination of the informational macromolecules responsible for transfer of genetic information and synthesis of specific proteins in a developing cell may lead to a better understandinig of the molecular basis of growth and differentiation. The embryonic development of amphibians and echinoderms has been most extensively studied irn an attempt to define the mechanisms of differentiation.' Evidence exists which indicates that the onset of protein synthesis in early embryogenesis represents the activation of pre-existing messenger RNA (mRNA) molecules rather t,han the de novo synthesis of new messages.2-6 However, other investigators7' 8 have reported that new mRNA molecules arise during late developmental stages of the sea urchin. Similarly, Denis9 compared the mRNA population of the mature amphibian egg and early cleaving embryo by means of RNA-DNA hybridization and competition methods and demonstrated that egg RNA was ineffective as a competitor, and thus appeared to contain no mRNA sequences in common with those synthesized late in development. The chick oviduct model system'0 appeared particularly suited for the study of mRNA populations during different stages of hormone-induced biochemical and cytological differentiation in higher animals. Growth and differentiation of the oviduct can be markedly stimulated by administration of diethylstilbestrol (DES) or estradiol to a newborn chick. After estrogen stimulation, three distinct types of epithelial cells differentiate from the homogeneousappearing cells of the mucosa.I Two of these cell types synthesize cell-specific proteins which can be measured biochemically and used as markers for differentiation.'2 We do not believe that DNA-RNA hybridization studies measure only mRNA; however, the technique should be feasible for indirectly assessing gene function by qualitatively identifying the appearance of new RNA transcriptions from different genetic loci during oviduct differentiation. In the present" @default.
- W2518532009 created "2016-09-16" @default.
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- W2518532009 date "2016-01-01" @default.
- W2518532009 modified "2023-09-26" @default.
- W2518532009 title "STUDIES ON THE MECIIANISMJ OF ESTROGEN-ME)DIA TED TISSUE DIFFEBkENT7A TION: REGULATION OF NUCLEA?1? TRANSCRIPTION AND INDUCTION OliF NEW RNA SPEOJE' S" @default.
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