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- W2518663711 abstract "The term 'prodrug' was first introduced by Albert in 1958. Generally, prodrugs can be utilized for improving active drug solubility and bioavailability, increasing drug permeability and absorption, modifying the distribution profile, preventing fast metabolism and excretion, and reducing toxicity. Previously, the prodrug approach was a final resort during the drug discovery process only after all other approaches had been exhausted. However, this strategy is now considered during the early stages of the drug development process. Most antitubercular agents are defined as 'prodrugs', including isoniazid and ethionamide. Thus, the prodrug approach could provide novel targets for the rational design of more effective treatments for tuberculosis (TB)." @default.
- W2518663711 created "2016-09-23" @default.
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- W2518663711 date "2017-03-01" @default.
- W2518663711 modified "2023-09-26" @default.
- W2518663711 title "New prodrugs against tuberculosis" @default.
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- W2518663711 doi "https://doi.org/10.1016/j.drudis.2016.09.006" @default.
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