Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518810011> ?p ?o ?g. }
- W2518810011 abstract "Abstract In this study, we aimed to investigate the dysfunction of zebrafish embryos and larvae induced by rac-/(+)-/(−)- PCB91 and rac-/(−)-/(+)- PCB149. UPLC-MS/MS (Ultra-performance liquid chromatography coupled with mass spectrometry) was employed to perform targeted metabolomics analysis, including the quantification of 22 amino acids and the semi-quantitation of 22 other metabolites. Stereoselective changes in target metabolites were observed in embryos and larvae after exposure to chiral PCB91 and PCB149, respectively. In addition, statistical analyses, including PCA and PLS-DA, combined with targeted metabolomics were conducted to identify the characteristic metabolites and the affected pathways. Most of the unique metabolites in embryos and larvae after PCB91/149 exposure were amino acids, and the affected pathways for zebrafish in the developmental stage were metabolic pathways. The stereoselective effects of PCB91/149 on the metabolic pathways of zebrafish embryos and larvae suggest that chiral PCB91/149 exposure has stereoselective toxicity on the developmental stages of zebrafish." @default.
- W2518810011 created "2016-09-23" @default.
- W2518810011 creator A5002329844 @default.
- W2518810011 creator A5018946004 @default.
- W2518810011 creator A5038210379 @default.
- W2518810011 creator A5049692788 @default.
- W2518810011 creator A5062500062 @default.
- W2518810011 creator A5081620868 @default.
- W2518810011 date "2016-09-15" @default.
- W2518810011 modified "2023-10-18" @default.
- W2518810011 title "Chiral PCB 91 and 149 Toxicity Testing in Embryo and Larvae (Danio rerio): Application of Targeted Metabolomics via UPLC-MS/MS" @default.
- W2518810011 cites W1017749273 @default.
- W2518810011 cites W1660117397 @default.
- W2518810011 cites W1898832292 @default.
- W2518810011 cites W1964452663 @default.
- W2518810011 cites W1975070511 @default.
- W2518810011 cites W1981062611 @default.
- W2518810011 cites W1984095783 @default.
- W2518810011 cites W1987752687 @default.
- W2518810011 cites W1987933355 @default.
- W2518810011 cites W1988567200 @default.
- W2518810011 cites W1991001716 @default.
- W2518810011 cites W1994103322 @default.
- W2518810011 cites W1997294983 @default.
- W2518810011 cites W1997890872 @default.
- W2518810011 cites W1997975781 @default.
- W2518810011 cites W2001860174 @default.
- W2518810011 cites W2014185324 @default.
- W2518810011 cites W2015050118 @default.
- W2518810011 cites W2016886596 @default.
- W2518810011 cites W2021322411 @default.
- W2518810011 cites W2022980475 @default.
- W2518810011 cites W2035104998 @default.
- W2518810011 cites W2035676134 @default.
- W2518810011 cites W2036413416 @default.
- W2518810011 cites W2038307361 @default.
- W2518810011 cites W2060715824 @default.
- W2518810011 cites W2068542211 @default.
- W2518810011 cites W2073596624 @default.
- W2518810011 cites W2083375319 @default.
- W2518810011 cites W2089686111 @default.
- W2518810011 cites W2091373950 @default.
- W2518810011 cites W2097292628 @default.
- W2518810011 cites W2097676078 @default.
- W2518810011 cites W2098742258 @default.
- W2518810011 cites W2105732317 @default.
- W2518810011 cites W2126506452 @default.
- W2518810011 cites W2132753818 @default.
- W2518810011 cites W2149206139 @default.
- W2518810011 cites W2150779565 @default.
- W2518810011 cites W2162688524 @default.
- W2518810011 cites W2167847465 @default.
- W2518810011 cites W2170176313 @default.
- W2518810011 cites W2171520441 @default.
- W2518810011 cites W2230112742 @default.
- W2518810011 cites W2234202339 @default.
- W2518810011 cites W2274723035 @default.
- W2518810011 cites W2296417542 @default.
- W2518810011 cites W2318476459 @default.
- W2518810011 cites W2329917123 @default.
- W2518810011 cites W2346855792 @default.
- W2518810011 cites W2392933751 @default.
- W2518810011 cites W2419323311 @default.
- W2518810011 cites W2461362731 @default.
- W2518810011 cites W2913666085 @default.
- W2518810011 cites W828252478 @default.
- W2518810011 doi "https://doi.org/10.1038/srep33481" @default.
- W2518810011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5024159" @default.
- W2518810011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27629264" @default.
- W2518810011 hasPublicationYear "2016" @default.
- W2518810011 type Work @default.
- W2518810011 sameAs 2518810011 @default.
- W2518810011 citedByCount "15" @default.
- W2518810011 countsByYear W25188100112017 @default.
- W2518810011 countsByYear W25188100112018 @default.
- W2518810011 countsByYear W25188100112019 @default.
- W2518810011 countsByYear W25188100112020 @default.
- W2518810011 countsByYear W25188100112021 @default.
- W2518810011 countsByYear W25188100112023 @default.
- W2518810011 crossrefType "journal-article" @default.
- W2518810011 hasAuthorship W2518810011A5002329844 @default.
- W2518810011 hasAuthorship W2518810011A5018946004 @default.
- W2518810011 hasAuthorship W2518810011A5038210379 @default.
- W2518810011 hasAuthorship W2518810011A5049692788 @default.
- W2518810011 hasAuthorship W2518810011A5062500062 @default.
- W2518810011 hasAuthorship W2518810011A5081620868 @default.
- W2518810011 hasBestOaLocation W25188100111 @default.
- W2518810011 hasConcept C104317684 @default.
- W2518810011 hasConcept C135870905 @default.
- W2518810011 hasConcept C161790260 @default.
- W2518810011 hasConcept C172680121 @default.
- W2518810011 hasConcept C178790620 @default.
- W2518810011 hasConcept C179335377 @default.
- W2518810011 hasConcept C181647583 @default.
- W2518810011 hasConcept C185592680 @default.
- W2518810011 hasConcept C192989942 @default.
- W2518810011 hasConcept C196843134 @default.
- W2518810011 hasConcept C21565614 @default.
- W2518810011 hasConcept C2776878037 @default.
- W2518810011 hasConcept C2777477808 @default.