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• W2518831915 endingPage "2702" @default.
• W2518831915 startingPage "2691" @default.
• W2518831915 abstract "BACKGROUND Phosphorylation status of the transcription factor CCAAT/enhancer binding protein α (C/EBPα) has been demonstrated in a human hematopoietic cell model to regulate the formation of branched I antigen by affecting its binding affinity to the promoter region of the IGnTC gene during erythroid and granulocytic differentiation. STUDY DESIGN AND METHODS The K‐562 cell line was induced to differentiate into red blood cells (RBCs) or granulocytes by sodium butyrate or retinoic acid, respectively, to study the involvement of three MAP kinase pathways in I antigen synthesis. The regulatory effects of the extracellular signal‐regulated kinase (ERK)2‐Src homology region 2 domain‐containing phosphatase 2 (SHP2) pathway on phosphorylation status and binding affinities of C/EBPα as well as the subsequent activation of IGnTC and synthesis of surface I formation were studied in wild‐type K‐562 cells and in mutant cells that overexpress ERK2 and SHP2. RESULTS We found that SHP2‐ERK2 signaling regulates the phosphorylation status of C/EBPα to alter its binding affinity onto the IGnTC promoter region, thereby activating the synthesis of cell surface I antigen formation during erythropoiesis. CONCLUSION SHP2‐ERK2 signaling acts upstream of C/EBPα as a regulator of cell surface I antigen synthesis. Such regulation is specific for RBC but not for granulocyte differentiation." @default.
• W2518831915 created "2016-09-23" @default.
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• W2518831915 date "2016-09-07" @default.
• W2518831915 modified "2023-10-12" @default.
• W2518831915 title "The SHP2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of CCAAT/enhancer binding protein α to the<i>IGnTC</i>promoter region during erythroid differentiation" @default.
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• W2518831915 doi "https://doi.org/10.1111/trf.13796" @default.
• W2518831915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27600951" @default.
• W2518831915 hasPublicationYear "2016" @default.
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