FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518865156> ?p ?o ?g. }

• W2518865156 endingPage "2897" @default.
• W2518865156 startingPage "2881" @default.
• W2518865156 abstract "The cellular cytoskeleton forms the primary basis through which a cell governs the changes in size, shape, migration, proliferation, and forms the primary means through which the cells respond to their environment. Indeed, cell and tissue morphologies are used routinely not only to grade tumors but also in various high-content screening methods with an aim to identify new small molecules with therapeutic potential. This study examines the expression of various cytoskeleton regulators in glioblastoma multiforme (GBM). GBM is a very aggressive disease with a low life expectancy even after chemo- and radiotherapy. Cancer cells of GBM are notorious for their invasiveness, ability to develop resistance to chemo- and radiotherapy, and to form secondary site tumors. This study aims to gain insight into cytoskeleton regulators in GBM cells and to understand the effect of various oncology drugs, including temozolomide, on cytoskeleton regulators. We compare the expression of various cytoskeleton regulators in GBM-derived tumor and normal tissue, CD133-postive and -negative cells from GBM and neural cells, and GBM stem-like and differentiated cells. In addition, the correlation between the expression of cytoskeleton regulators with the clinical outcome was examined to identify genes associated with longer patient survival. This was followed by a small molecule screening with US Food and Drug Administration (FDA)-approved oncology drugs, and its effect on cellular cytoskeleton was compared to treatment with temozolomide. This study identifies various groups of cytoskeletal regulators that have an important effect on patient survival and tumor development. Importantly, this work highlights the advantage of using cytoskeleton regulators as biomarkers for assessing prognosis and treatment design for GBM." @default.
• W2518865156 created "2016-09-23" @default.
• W2518865156 creator A5010537664 @default.
• W2518865156 creator A5029061671 @default.
• W2518865156 creator A5032322538 @default.
• W2518865156 creator A5040172731 @default.
• W2518865156 creator A5042449384 @default.
• W2518865156 creator A5046609170 @default.
• W2518865156 creator A5055154748 @default.
• W2518865156 creator A5071240532 @default.
• W2518865156 creator A5090228475 @default.
• W2518865156 date "2016-09-01" @default.
• W2518865156 modified "2023-10-18" @default.
• W2518865156 title "Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design" @default.
• W2518865156 cites W1486445524 @default.
• W2518865156 cites W1520020505 @default.
• W2518865156 cites W1838136827 @default.
• W2518865156 cites W1893588436 @default.
• W2518865156 cites W1964966987 @default.
• W2518865156 cites W1973944247 @default.
• W2518865156 cites W1974009908 @default.
• W2518865156 cites W1979988883 @default.
• W2518865156 cites W2007613815 @default.
• W2518865156 cites W2019226300 @default.
• W2518865156 cites W2020786750 @default.
• W2518865156 cites W2025183726 @default.
• W2518865156 cites W2033455478 @default.
• W2518865156 cites W2034933577 @default.
• W2518865156 cites W2040827479 @default.
• W2518865156 cites W2046461201 @default.
• W2518865156 cites W2054333460 @default.
• W2518865156 cites W2075887159 @default.
• W2518865156 cites W2094492329 @default.
• W2518865156 cites W2096287682 @default.
• W2518865156 cites W2098708609 @default.
• W2518865156 cites W2105100844 @default.
• W2518865156 cites W2109816625 @default.
• W2518865156 cites W2110711017 @default.
• W2518865156 cites W2110909153 @default.
• W2518865156 cites W2114843025 @default.
• W2518865156 cites W2125148620 @default.
• W2518865156 cites W2134447603 @default.
• W2518865156 cites W2135168051 @default.
• W2518865156 cites W2138078973 @default.
• W2518865156 cites W2140295139 @default.
• W2518865156 cites W2140721485 @default.
• W2518865156 cites W2148977460 @default.
• W2518865156 cites W2149441684 @default.
• W2518865156 cites W2158681922 @default.
• W2518865156 cites W2160382843 @default.
• W2518865156 cites W2162328939 @default.
• W2518865156 cites W2164156561 @default.
• W2518865156 cites W2165520202 @default.
• W2518865156 cites W2165871546 @default.
• W2518865156 cites W2172097735 @default.
• W2518865156 cites W2335943770 @default.
• W2518865156 cites W3149313519 @default.
• W2518865156 cites W4229936717 @default.
• W2518865156 cites W4242403727 @default.
• W2518865156 doi "https://doi.org/10.2147/dddt.s106196" @default.
• W2518865156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5026218" @default.
• W2518865156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27672311" @default.
• W2518865156 hasPublicationYear "2016" @default.
• W2518865156 type Work @default.
• W2518865156 sameAs 2518865156 @default.
• W2518865156 citedByCount "14" @default.
• W2518865156 countsByYear W25188651562017 @default.
• W2518865156 countsByYear W25188651562018 @default.
• W2518865156 countsByYear W25188651562019 @default.
• W2518865156 countsByYear W25188651562020 @default.
• W2518865156 countsByYear W25188651562021 @default.
• W2518865156 countsByYear W25188651562022 @default.
• W2518865156 countsByYear W25188651562023 @default.
• W2518865156 crossrefType "journal-article" @default.
• W2518865156 hasAuthorship W2518865156A5010537664 @default.
• W2518865156 hasAuthorship W2518865156A5029061671 @default.
• W2518865156 hasAuthorship W2518865156A5032322538 @default.
• W2518865156 hasAuthorship W2518865156A5040172731 @default.
• W2518865156 hasAuthorship W2518865156A5042449384 @default.
• W2518865156 hasAuthorship W2518865156A5046609170 @default.
• W2518865156 hasAuthorship W2518865156A5055154748 @default.
• W2518865156 hasAuthorship W2518865156A5071240532 @default.
• W2518865156 hasAuthorship W2518865156A5090228475 @default.
• W2518865156 hasBestOaLocation W25188651561 @default.
• W2518865156 hasConcept C126322002 @default.
• W2518865156 hasConcept C142669718 @default.
• W2518865156 hasConcept C143998085 @default.
• W2518865156 hasConcept C1491633281 @default.
• W2518865156 hasConcept C2776194525 @default.
• W2518865156 hasConcept C2777389519 @default.
• W2518865156 hasConcept C28328180 @default.
• W2518865156 hasConcept C502942594 @default.
• W2518865156 hasConcept C509974204 @default.
• W2518865156 hasConcept C54355233 @default.
• W2518865156 hasConcept C55427017 @default.
• W2518865156 hasConcept C71924100 @default.
• W2518865156 hasConcept C86803240 @default.
• W2518865156 hasConcept C95444343 @default.

• next