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- W2519003850 endingPage "2756" @default.
- W2519003850 startingPage "2737" @default.
- W2519003850 abstract "Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance and hyperinsulinemia in early disease stages but a relative insulin insufficiency in later stages. Insulin, a peptide hormone, is produced in and secreted from pancreatic β-cells following elevated blood glucose levels. Upon its release, insulin induces the removal of excessive exogenous glucose from the bloodstream primarily by stimulating glucose uptake into insulin-dependent tissues as well as promoting hepatic glycogenesis. Given the increasing prevalence of T2DM worldwide, elucidating the underlying mechanisms and identifying the various players involved in the synthesis and exocytosis of insulin from β-cells is of utmost importance. This review summarizes our current understanding of the route insulin takes through the cell after its synthesis in the endoplasmic reticulum as well as our knowledge of the highly elaborate network that controls insulin release from the β-cell. This network harbors potential targets for anti-diabetic drugs and is regulated by signaling cascades from several endocrine systems." @default.
- W2519003850 created "2016-09-23" @default.
- W2519003850 creator A5014023198 @default.
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- W2519003850 creator A5084146581 @default.
- W2519003850 creator A5085103385 @default.
- W2519003850 date "2016-09-12" @default.
- W2519003850 modified "2023-10-03" @default.
- W2519003850 title "Molecular regulation of insulin granule biogenesis and exocytosis" @default.
- W2519003850 cites W1489286522 @default.
- W2519003850 cites W1506521906 @default.
- W2519003850 cites W1509143146 @default.
- W2519003850 cites W1511501308 @default.
- W2519003850 cites W1516572497 @default.
- W2519003850 cites W1537392408 @default.
- W2519003850 cites W1570745179 @default.
- W2519003850 cites W1580646470 @default.
- W2519003850 cites W1587875458 @default.
- W2519003850 cites W1590230114 @default.
- W2519003850 cites W1597390857 @default.
- W2519003850 cites W1674260863 @default.
- W2519003850 cites W1702317583 @default.
- W2519003850 cites W1808967316 @default.
- W2519003850 cites W1832118158 @default.
- W2519003850 cites W1907518241 @default.
- W2519003850 cites W1913308306 @default.
- W2519003850 cites W1964975939 @default.
- W2519003850 cites W1965710275 @default.
- W2519003850 cites W1966428323 @default.
- W2519003850 cites W1967821213 @default.
- W2519003850 cites W1968031607 @default.
- W2519003850 cites W1968720990 @default.
- W2519003850 cites W1970076105 @default.
- W2519003850 cites W1970979984 @default.
- W2519003850 cites W1971881171 @default.
- W2519003850 cites W1975250137 @default.
- W2519003850 cites W1975507912 @default.
- W2519003850 cites W1975969445 @default.
- W2519003850 cites W1978982233 @default.
- W2519003850 cites W1979768668 @default.
- W2519003850 cites W1979855720 @default.
- W2519003850 cites W1981183973 @default.
- W2519003850 cites W1981697489 @default.
- W2519003850 cites W1982602254 @default.
- W2519003850 cites W1983009379 @default.
- W2519003850 cites W1983286754 @default.
- W2519003850 cites W1983423690 @default.
- W2519003850 cites W1985282777 @default.
- W2519003850 cites W1985464997 @default.
- W2519003850 cites W1986630397 @default.
- W2519003850 cites W1986958367 @default.
- W2519003850 cites W1987278333 @default.
- W2519003850 cites W1987579406 @default.
- W2519003850 cites W1987778629 @default.
- W2519003850 cites W1989294105 @default.
- W2519003850 cites W1989817905 @default.
- W2519003850 cites W1990887711 @default.
- W2519003850 cites W1992002046 @default.
- W2519003850 cites W1992163176 @default.
- W2519003850 cites W1993215622 @default.
- W2519003850 cites W1994320162 @default.
- W2519003850 cites W1994630156 @default.
- W2519003850 cites W1995273617 @default.
- W2519003850 cites W1997335175 @default.
- W2519003850 cites W1999213641 @default.
- W2519003850 cites W1999252792 @default.
- W2519003850 cites W1999495877 @default.
- W2519003850 cites W1999976970 @default.
- W2519003850 cites W2001300907 @default.
- W2519003850 cites W2001648811 @default.
- W2519003850 cites W2003364705 @default.
- W2519003850 cites W2003557985 @default.
- W2519003850 cites W2003822998 @default.
- W2519003850 cites W2004564781 @default.
- W2519003850 cites W2004797151 @default.
- W2519003850 cites W2005270516 @default.
- W2519003850 cites W2006406278 @default.
- W2519003850 cites W2009320519 @default.
- W2519003850 cites W2009480581 @default.
- W2519003850 cites W2011940688 @default.
- W2519003850 cites W2012623603 @default.
- W2519003850 cites W2012629717 @default.
- W2519003850 cites W2013739856 @default.
- W2519003850 cites W2013849517 @default.
- W2519003850 cites W2014241029 @default.
- W2519003850 cites W2015316095 @default.
- W2519003850 cites W2015463169 @default.
- W2519003850 cites W2018757497 @default.
- W2519003850 cites W2020077746 @default.
- W2519003850 cites W2020115894 @default.
- W2519003850 cites W2020821717 @default.
- W2519003850 cites W2022297126 @default.
- W2519003850 cites W2022430914 @default.
- W2519003850 cites W2024253268 @default.
- W2519003850 cites W2025399834 @default.
- W2519003850 cites W2025872971 @default.
- W2519003850 cites W2027175865 @default.
- W2519003850 cites W2027593203 @default.