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- W2519006730 endingPage "12233" @default.
- W2519006730 startingPage "12150" @default.
- W2519006730 abstract "The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic intermediate. These applications have driven numerous studies into the synthesis of new oxetane derivatives. This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015. These methods are clustered by strategies for preparation of the ring and further derivatization of preformed oxetane-containing building blocks. Examples of the use of oxetanes in medicinal chemistry are reported, including a collation of oxetane derivatives appearing in recent patents for medicinal chemistry applications. Finally, examples of oxetane derivatives in ring-opening and ring-expansion reactions are described." @default.
- W2519006730 created "2016-09-23" @default.
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- W2519006730 creator A5075660331 @default.
- W2519006730 date "2016-09-15" @default.
- W2519006730 modified "2023-10-15" @default.
- W2519006730 title "Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry" @default.
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