FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519048082> ?p ?o ?g. }

• W2519048082 endingPage "836" @default.
• W2519048082 startingPage "823" @default.
• W2519048082 abstract "An improved understanding of pathogenic pathways in AKI may identify novel therapeutic approaches. Previously, we conducted unbiased liquid chromatography-tandem mass spectrometry-based protein expression profiling of the renal proteome in mice with acute folate nephropathy. Here, analysis of the dataset identified enrichment of pathways involving NFκB in the kidney cortex, and a targeted data mining approach identified components of the noncanonical NFκB pathway, including the upstream kinase mitogen-activated protein kinase kinase kinase 14 (MAP3K14), the NFκB DNA binding heterodimer RelB/NFκB2, and proteins involved in NFκB2 p100 ubiquitination and proteasomal processing to p52, as upregulated. Immunohistochemistry localized MAP3K14 expression to tubular cells in acute folate nephropathy and human AKI. In vivo, kidney expression levels of NFκB2 p100 and p52 increased rapidly after folic acid injection, as did DNA binding of RelB and NFκB2, detected in nuclei isolated from the kidneys. Compared with wild-type mice, MAP3K14 activity-deficient aly/aly (MAP3K14aly/aly) mice had less kidney dysfunction, inflammation, and apoptosis in acute folate nephropathy and less kidney dysfunction and a lower mortality rate in cisplatin-induced AKI. The exchange of bone marrow between wild-type and MAP3K14aly/aly mice did not affect the survival rate of either group after folic acid injection. In cultured tubular cells, MAP3K14 small interfering RNA targeting decreased inflammation and cell death. Additionally, cell culture and in vivo studies identified the chemokines MCP-1, RANTES, and CXCL10 as MAP3K14 targets in tubular cells. In conclusion, MAP3K14 promotes kidney injury through promotion of inflammation and cell death and is a promising novel therapeutic target." @default.
• W2519048082 created "2016-09-23" @default.
• W2519048082 creator A5009943624 @default.
• W2519048082 creator A5012999223 @default.
• W2519048082 creator A5022080798 @default.
• W2519048082 creator A5030157600 @default.
• W2519048082 creator A5032779155 @default.
• W2519048082 creator A5035999325 @default.
• W2519048082 creator A5042966344 @default.
• W2519048082 creator A5045038056 @default.
• W2519048082 creator A5052560289 @default.
• W2519048082 creator A5063080095 @default.
• W2519048082 creator A5063245254 @default.
• W2519048082 date "2016-09-12" @default.
• W2519048082 modified "2023-10-17" @default.
• W2519048082 title "Mitogen-Activated Protein Kinase 14 Promotes AKI" @default.
• W2519048082 cites W1501881225 @default.
• W2519048082 cites W1558901013 @default.
• W2519048082 cites W1567453654 @default.
• W2519048082 cites W1641228030 @default.
• W2519048082 cites W1650742008 @default.
• W2519048082 cites W1694093395 @default.
• W2519048082 cites W1872111533 @default.
• W2519048082 cites W1946164369 @default.
• W2519048082 cites W1965256404 @default.
• W2519048082 cites W1970533338 @default.
• W2519048082 cites W1987531976 @default.
• W2519048082 cites W1991334711 @default.
• W2519048082 cites W2002066494 @default.
• W2519048082 cites W2004673647 @default.
• W2519048082 cites W2012615147 @default.
• W2519048082 cites W2013211110 @default.
• W2519048082 cites W2018749567 @default.
• W2519048082 cites W2019442978 @default.
• W2519048082 cites W2021056570 @default.
• W2519048082 cites W2024513761 @default.
• W2519048082 cites W2029746669 @default.
• W2519048082 cites W2032040575 @default.
• W2519048082 cites W2035999971 @default.
• W2519048082 cites W2037334368 @default.
• W2519048082 cites W2037854608 @default.
• W2519048082 cites W2040342205 @default.
• W2519048082 cites W2041393180 @default.
• W2519048082 cites W2042953533 @default.
• W2519048082 cites W2043150560 @default.
• W2519048082 cites W2043798682 @default.
• W2519048082 cites W2048615690 @default.
• W2519048082 cites W2049761545 @default.
• W2519048082 cites W2057048644 @default.
• W2519048082 cites W2059113149 @default.
• W2519048082 cites W2059301162 @default.
• W2519048082 cites W2060778210 @default.
• W2519048082 cites W2075273683 @default.
• W2519048082 cites W2076465180 @default.
• W2519048082 cites W2098912300 @default.
• W2519048082 cites W2100048287 @default.
• W2519048082 cites W2102244214 @default.
• W2519048082 cites W2107628049 @default.
• W2519048082 cites W2107841117 @default.
• W2519048082 cites W2111142153 @default.
• W2519048082 cites W2115883914 @default.
• W2519048082 cites W2118385164 @default.
• W2519048082 cites W2122380860 @default.
• W2519048082 cites W2133072698 @default.
• W2519048082 cites W2134887638 @default.
• W2519048082 cites W2135702644 @default.
• W2519048082 cites W2135800410 @default.
• W2519048082 cites W2135835434 @default.
• W2519048082 cites W2143763048 @default.
• W2519048082 cites W2144657330 @default.
• W2519048082 cites W2146081758 @default.
• W2519048082 cites W2150401175 @default.
• W2519048082 cites W2156791331 @default.
• W2519048082 cites W2158646961 @default.
• W2519048082 cites W2158703921 @default.
• W2519048082 cites W2162177054 @default.
• W2519048082 cites W2168828068 @default.
• W2519048082 cites W2169393475 @default.
• W2519048082 cites W2171298110 @default.
• W2519048082 cites W2171966337 @default.
• W2519048082 cites W4231980339 @default.
• W2519048082 cites W4246561197 @default.
• W2519048082 doi "https://doi.org/10.1681/asn.2015080898" @default.
• W2519048082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5328147" @default.
• W2519048082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27620989" @default.
• W2519048082 hasPublicationYear "2016" @default.
• W2519048082 type Work @default.
• W2519048082 sameAs 2519048082 @default.
• W2519048082 citedByCount "33" @default.
• W2519048082 countsByYear W25190480822016 @default.
• W2519048082 countsByYear W25190480822017 @default.
• W2519048082 countsByYear W25190480822018 @default.
• W2519048082 countsByYear W25190480822019 @default.
• W2519048082 countsByYear W25190480822020 @default.
• W2519048082 countsByYear W25190480822021 @default.
• W2519048082 countsByYear W25190480822022 @default.
• W2519048082 countsByYear W25190480822023 @default.
• W2519048082 crossrefType "journal-article" @default.

• next