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- W2519064057 abstract "Objective: To examine the association between admission volume depletion (BUN/SCr > 15) and discharge outcome in AIS patients.Background: Few large studies exist on volume depletion and its association with outcomes in acute ischemic stroke (AIS) patients. A common marker of volume status is the calculated blood urea nitrogen (BUN) to serum creatinine (SCr) ratio.Methods: Consecutive patients (March 2014 - April 2015) who presented with AIS to our Comprehensive Stroke Center (CSC) were retrospectively analyzed. Demographics, medical history, imaging, initial lab values, stroke severity (NIHSS), and discharge disposition were recorded. Patients BUN/SCr (less than or equal to 15 vs. greater than 15) were compared and good outcome defined as discharge home. We performed logistic regression adjusting for admission NIHSS and age.Results: We identified 776 patients who met inclusion criteria. Patients with BUN/SCr >15, were older (median 61 vs. 68, p 15 was associated with lower odds of good outcome at discharge (OR=0.57, 0.42 - 0.78; p<0.001), this relationship persisted after adjusting for known predictors (OR=0.70, 0.49 -1.00; p=0.055).Conclusions: After controlling for NIHSS and age, volume depletion in AIS patients estimated by BUN/SCr ratio was associated with poor discharge outcome, complicated hospital course, increased LOS, and in-hospital mortality. This simple ratio can be used in the early evaluation and treatment of AIS. However, multi-center prospective studies are needed to determine if volume correction is confounding this association. Disclosure: Dr. Shiue has nothing to disclose. Dr. Albright has nothing to disclose. Dr. Sands has received research support from Biogen. Dr. Sisson has nothing to disclose. Dr. Bavarsad Shahripour has nothing to disclose. Dr. Lyerly has nothing to disclose. Dr. Arora has nothing to disclose. Dr. Gadpaille has nothing to disclose. Dr. Khawaja has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Gropen has nothing to disclose." @default.
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- W2519064057 date "2016-04-05" @default.
- W2519064057 modified "2023-09-22" @default.
- W2519064057 title "Admission Volume Depletion is Associated with Poor Outcome in Acute Ischemic Stroke (P1.192)" @default.
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