Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519070551> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2519070551 endingPage "328" @default.
- W2519070551 startingPage "317" @default.
- W2519070551 abstract "Plasma concentrations of isosorbide-5-mononitrate (5-ISMN) (TY-10368) measured: (1) after oral doses of 10 mg at fasting or at 1.5 hr after meal in 3 subjects with one week between dosing sessions, (2) after oral doses of 10, 20 40 mg in 6 subjects and (3) after repeated oral doses of 20 mg at 12-hr intervals 84 hr in 6 subjects. Food intake reduced the peak plasma concentrations of ISMN, but did not affect the extent of bioavailability from oral dosing after an overnight fast. Maximum plasma concentrations were achieved within the same range time after all doses: an average of 1.7 hr±0.2 (SD; non-fasting). The pharmaco-kinetics showed dose-lineality, since the peak plasma concentrations and the total area under the curve (AUC) were proportional to dose administered. The elim ination half-lives after administration of all doses were in the range of 5-6 hr, with narrow interindividual variation. The total amounts of free and conjugated 5-ISMN excreted into the urine over 60 hr were proportional to dose administered within a range of 22-36%, and only a trace amount was detected at 24 hr after dose.Repeated administration at 12-hr intervals during 84 hr did not increase the minimal plasma concentration or elimination half-life without significant increase of time to peak plasma concentration.Whereas the diastolic blood pressure did not change systematically, average falls in the systolic blood pressure of 6.2%, 10.3% and 12.3% were observed at the time of the peak plasma levels after single oral dose of 10, 20 and 40 mg, respectively. There was no significant correlation between maximum plasma 5-ISMN levels and corresponding systolic blood pressure reduction.The plasma cyclic GMP concentrations determined when the peak 5-ISMN plasma levels were achieved or when the maximal systolic blood pressure reductions were noted, decreased significantly after oral doses of 20 mg, but the highest dose did not change the plasma cyclic GMP levels significantly.All subjects complained of a headache or felt heavy-headedness which did not seem to be dose-dependent, and mentioned no symptoms at 24 hr after TY-10368 administration." @default.
- W2519070551 created "2016-09-23" @default.
- W2519070551 creator A5025413774 @default.
- W2519070551 creator A5034561662 @default.
- W2519070551 creator A5037004775 @default.
- W2519070551 creator A5045942388 @default.
- W2519070551 creator A5062064920 @default.
- W2519070551 date "1984-01-01" @default.
- W2519070551 modified "2023-10-06" @default.
- W2519070551 cites W1967592999 @default.
- W2519070551 cites W1969569426 @default.
- W2519070551 cites W1979871046 @default.
- W2519070551 cites W1988884653 @default.
- W2519070551 cites W2002643977 @default.
- W2519070551 cites W2060739597 @default.
- W2519070551 cites W2099034520 @default.
- W2519070551 cites W2143695297 @default.
- W2519070551 cites W217734271 @default.
- W2519070551 cites W2257974376 @default.
- W2519070551 cites W2258411363 @default.
- W2519070551 cites W2298292152 @default.
- W2519070551 cites W2415130596 @default.
- W2519070551 cites W2415190536 @default.
- W2519070551 cites W647421906 @default.
- W2519070551 doi "https://doi.org/10.3999/jscpt.15.317" @default.
- W2519070551 hasPublicationYear "1984" @default.
- W2519070551 type Work @default.
- W2519070551 sameAs 2519070551 @default.
- W2519070551 citedByCount "1" @default.
- W2519070551 crossrefType "journal-article" @default.
- W2519070551 hasAuthorship W2519070551A5025413774 @default.
- W2519070551 hasAuthorship W2519070551A5034561662 @default.
- W2519070551 hasAuthorship W2519070551A5037004775 @default.
- W2519070551 hasAuthorship W2519070551A5045942388 @default.
- W2519070551 hasAuthorship W2519070551A5062064920 @default.
- W2519070551 hasBestOaLocation W25190705511 @default.
- W2519070551 hasConcept C112705442 @default.
- W2519070551 hasConcept C126322002 @default.
- W2519070551 hasConcept C140793950 @default.
- W2519070551 hasConcept C181389837 @default.
- W2519070551 hasConcept C2777056448 @default.
- W2519070551 hasConcept C2777288759 @default.
- W2519070551 hasConcept C2778345441 @default.
- W2519070551 hasConcept C2778492647 @default.
- W2519070551 hasConcept C2780026642 @default.
- W2519070551 hasConcept C3020079912 @default.
- W2519070551 hasConcept C3941253 @default.
- W2519070551 hasConcept C71924100 @default.
- W2519070551 hasConcept C84393581 @default.
- W2519070551 hasConcept C86803240 @default.
- W2519070551 hasConcept C98274493 @default.
- W2519070551 hasConceptScore W2519070551C112705442 @default.
- W2519070551 hasConceptScore W2519070551C126322002 @default.
- W2519070551 hasConceptScore W2519070551C140793950 @default.
- W2519070551 hasConceptScore W2519070551C181389837 @default.
- W2519070551 hasConceptScore W2519070551C2777056448 @default.
- W2519070551 hasConceptScore W2519070551C2777288759 @default.
- W2519070551 hasConceptScore W2519070551C2778345441 @default.
- W2519070551 hasConceptScore W2519070551C2778492647 @default.
- W2519070551 hasConceptScore W2519070551C2780026642 @default.
- W2519070551 hasConceptScore W2519070551C3020079912 @default.
- W2519070551 hasConceptScore W2519070551C3941253 @default.
- W2519070551 hasConceptScore W2519070551C71924100 @default.
- W2519070551 hasConceptScore W2519070551C84393581 @default.
- W2519070551 hasConceptScore W2519070551C86803240 @default.
- W2519070551 hasConceptScore W2519070551C98274493 @default.
- W2519070551 hasIssue "2" @default.
- W2519070551 hasLocation W25190705511 @default.
- W2519070551 hasOpenAccess W2519070551 @default.
- W2519070551 hasPrimaryLocation W25190705511 @default.
- W2519070551 hasRelatedWork W1704380393 @default.
- W2519070551 hasRelatedWork W1990788570 @default.
- W2519070551 hasRelatedWork W2004325424 @default.
- W2519070551 hasRelatedWork W2009820498 @default.
- W2519070551 hasRelatedWork W2025672211 @default.
- W2519070551 hasRelatedWork W2034956313 @default.
- W2519070551 hasRelatedWork W2047715947 @default.
- W2519070551 hasRelatedWork W2092069111 @default.
- W2519070551 hasRelatedWork W2793520024 @default.
- W2519070551 hasRelatedWork W4252988432 @default.
- W2519070551 hasVolume "15" @default.
- W2519070551 isParatext "false" @default.
- W2519070551 isRetracted "false" @default.
- W2519070551 magId "2519070551" @default.
- W2519070551 workType "article" @default.