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• W2519127568 abstract "The clinical benefits of short-term therapy with glucocorticoids (GC) in patients with inflammatory bowel disease (IBD) are widely known. However, the effects of this treatment towards the re-establishment of the regulatory network in IBD are not fully explored. We have evaluated the immunological effects of the abbreviated GC therapy in experimental colitis induced by 3% dextran sulphate sodium in C57BL/6 mice. Treatment with GC improved disease outcome, constrained circulating leucocytes and ameliorated intestinal inflammation. The control of the local inflammatory responses involved a reduction in the expression of interferon-γ and interleukin-1β, associated with augmented mRNA levels of peroxisome proliferator-activated receptors (α and γ) in intestine. Furthermore, there was a reduction of CD4+ T cells producing interferon-γ, together with an increased frequency of the putative regulatory population of T cells producing interleukin-10, in spleen. These systemic alterations were accompanied by a decrease in the proliferative potential of splenocytes of mice treated in vivo with GC. Notably, treatment with GC also led to an increase in the frequency of the regulatory markers GITR, CTLA-4, PD-1, CD73 and FoxP3, more prominently in spleen. Taken together, our results pointed to a role of GC in the control of leucocyte responsiveness and re-establishment of a regulatory system, which probably contributed to disease control and the restoration of immune balance. Finally, this is the first time that GC treatment was associated with the modulation of a broad number of regulatory markers in an experimental model of colitis." @default.
• W2519127568 created "2016-09-23" @default.
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• W2519127568 date "2016-10-07" @default.
• W2519127568 modified "2023-10-17" @default.
• W2519127568 title "Amelioration of experimental colitis after short-term therapy with glucocorticoid and its relationship to the induction of different regulatory markers" @default.
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• W2519127568 cites W1519063308 @default.
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• W2519127568 cites W1552751328 @default.
• W2519127568 cites W1877755747 @default.
• W2519127568 cites W1911945597 @default.
• W2519127568 cites W1960393385 @default.
• W2519127568 cites W1962764685 @default.
• W2519127568 cites W1972347959 @default.
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• W2519127568 cites W1976796596 @default.
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• W2519127568 cites W2023308095 @default.
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• W2519127568 cites W2088781708 @default.
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• W2519127568 cites W2105484520 @default.
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• W2519127568 cites W2114044831 @default.
• W2519127568 cites W2116945335 @default.
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• W2519127568 cites W2150691073 @default.
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• W2519127568 cites W2155538342 @default.
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• W2519127568 cites W2165167811 @default.
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• W2519127568 doi "https://doi.org/10.1111/imm.12672" @default.
• W2519127568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5341502" @default.
• W2519127568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27618667" @default.
• W2519127568 hasPublicationYear "2016" @default.
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