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• W2519177776 endingPage "e0162761" @default.
• W2519177776 startingPage "e0162761" @default.
• W2519177776 abstract "In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating behavior. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located on the antenna called trichoid sensilla. In Drosophila there are two classes of trichoid sensilla, at1 sensilla that contain the dendrites of a single neuron that is specifically tuned to the male-specific pheromone 11-cis vaccenyl acetate (cVA), and at4 sensilla that contain three neurons with relatively poorly defined chemical specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, we have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. Our results indicate that one class, Or65abc neurons, are unresponsive to cVA pheromone, and function to inhibit courtship behaviors in response to an unknown ligand, while the other two neuron classes, Or88a and Or47b neurons, are sensitive to a diverse array of fly and non-fly odors, and activation of these neurons has little direct impact on courtship behaviors." @default.
• W2519177776 created "2016-09-23" @default.
• W2519177776 creator A5004447155 @default.
• W2519177776 creator A5004761719 @default.
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• W2519177776 date "2016-09-12" @default.
• W2519177776 modified "2023-10-16" @default.
• W2519177776 title "Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila" @default.
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• W2519177776 doi "https://doi.org/10.1371/journal.pone.0162761" @default.
• W2519177776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5019410" @default.
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• W2519177776 hasPublicationYear "2016" @default.
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