FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519197521> ?p ?o ?g. }

• W2519197521 abstract "During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development, Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a new role of Notch in nephrogenesis. We show that differentiation of nephron progenitors requires downregulation of Six2, a transcription factor required for progenitor maintenance, and that Notch signaling is necessary and sufficient for downregulation of Six2. Furthermore, we find that nephron progenitors lacking Notch signaling fail to differentiate into any nephron segments, not just proximal tubules. Our results demonstrate how cell fates of progenitors are regulated by a transcription factor governing progenitor status and a differentiation signal in nephrogenesis." @default.
• W2519197521 created "2016-09-23" @default.
• W2519197521 creator A5017262355 @default.
• W2519197521 creator A5045551349 @default.
• W2519197521 creator A5058181445 @default.
• W2519197521 creator A5059525122 @default.
• W2519197521 creator A5091169394 @default.
• W2519197521 date "2016-01-01" @default.
• W2519197521 modified "2023-10-16" @default.
• W2519197521 title "Notch signaling promotes nephrogenesis by downregulating Six2" @default.
• W2519197521 cites W1502534219 @default.
• W2519197521 cites W1689459472 @default.
• W2519197521 cites W1802574002 @default.
• W2519197521 cites W1971689970 @default.
• W2519197521 cites W1973483073 @default.
• W2519197521 cites W1980020302 @default.
• W2519197521 cites W1985623793 @default.
• W2519197521 cites W1987874305 @default.
• W2519197521 cites W1991003400 @default.
• W2519197521 cites W1991148912 @default.
• W2519197521 cites W1997631325 @default.
• W2519197521 cites W2001671102 @default.
• W2519197521 cites W2004410280 @default.
• W2519197521 cites W2006419043 @default.
• W2519197521 cites W2007195938 @default.
• W2519197521 cites W2029969016 @default.
• W2519197521 cites W2041572974 @default.
• W2519197521 cites W2053056402 @default.
• W2519197521 cites W2063936800 @default.
• W2519197521 cites W2063947701 @default.
• W2519197521 cites W2066484100 @default.
• W2519197521 cites W2074329168 @default.
• W2519197521 cites W2075080322 @default.
• W2519197521 cites W2084585178 @default.
• W2519197521 cites W2086677653 @default.
• W2519197521 cites W2109627278 @default.
• W2519197521 cites W2111410841 @default.
• W2519197521 cites W2131924342 @default.
• W2519197521 cites W2136160100 @default.
• W2519197521 cites W2136825322 @default.
• W2519197521 cites W2145111609 @default.
• W2519197521 cites W2145639699 @default.
• W2519197521 cites W2154992599 @default.
• W2519197521 cites W2192723508 @default.
• W2519197521 cites W2339280036 @default.
• W2519197521 cites W2415440329 @default.
• W2519197521 cites W4290300499 @default.
• W2519197521 cites W574521284 @default.
• W2519197521 doi "https://doi.org/10.1242/dev.143503" @default.
• W2519197521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5117151" @default.
• W2519197521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27633993" @default.
• W2519197521 hasPublicationYear "2016" @default.
• W2519197521 type Work @default.
• W2519197521 sameAs 2519197521 @default.
• W2519197521 citedByCount "50" @default.
• W2519197521 countsByYear W25191975212017 @default.
• W2519197521 countsByYear W25191975212018 @default.
• W2519197521 countsByYear W25191975212019 @default.
• W2519197521 countsByYear W25191975212020 @default.
• W2519197521 countsByYear W25191975212021 @default.
• W2519197521 countsByYear W25191975212022 @default.
• W2519197521 countsByYear W25191975212023 @default.
• W2519197521 crossrefType "journal-article" @default.
• W2519197521 hasAuthorship W2519197521A5017262355 @default.
• W2519197521 hasAuthorship W2519197521A5045551349 @default.
• W2519197521 hasAuthorship W2519197521A5058181445 @default.
• W2519197521 hasAuthorship W2519197521A5059525122 @default.
• W2519197521 hasAuthorship W2519197521A5091169394 @default.
• W2519197521 hasBestOaLocation W25191975211 @default.
• W2519197521 hasConcept C104317684 @default.
• W2519197521 hasConcept C127561419 @default.
• W2519197521 hasConcept C134018914 @default.
• W2519197521 hasConcept C148738053 @default.
• W2519197521 hasConcept C15729860 @default.
• W2519197521 hasConcept C161879069 @default.
• W2519197521 hasConcept C198826908 @default.
• W2519197521 hasConcept C201750760 @default.
• W2519197521 hasConcept C2780091579 @default.
• W2519197521 hasConcept C2781231759 @default.
• W2519197521 hasConcept C28328180 @default.
• W2519197521 hasConcept C54355233 @default.
• W2519197521 hasConcept C62478195 @default.
• W2519197521 hasConcept C86339819 @default.
• W2519197521 hasConcept C86803240 @default.
• W2519197521 hasConcept C95444343 @default.
• W2519197521 hasConceptScore W2519197521C104317684 @default.
• W2519197521 hasConceptScore W2519197521C127561419 @default.
• W2519197521 hasConceptScore W2519197521C134018914 @default.
• W2519197521 hasConceptScore W2519197521C148738053 @default.
• W2519197521 hasConceptScore W2519197521C15729860 @default.
• W2519197521 hasConceptScore W2519197521C161879069 @default.
• W2519197521 hasConceptScore W2519197521C198826908 @default.
• W2519197521 hasConceptScore W2519197521C201750760 @default.
• W2519197521 hasConceptScore W2519197521C2780091579 @default.
• W2519197521 hasConceptScore W2519197521C2781231759 @default.
• W2519197521 hasConceptScore W2519197521C28328180 @default.
• W2519197521 hasConceptScore W2519197521C54355233 @default.
• W2519197521 hasConceptScore W2519197521C62478195 @default.
• W2519197521 hasConceptScore W2519197521C86339819 @default.
• W2519197521 hasConceptScore W2519197521C86803240 @default.

• next