Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519253780> ?p ?o ?g. }
- W2519253780 endingPage "1105" @default.
- W2519253780 startingPage "1098" @default.
- W2519253780 abstract "Bed rest leads to rapid impairments in glucose tolerance. Plasma volume and thus dilution space for glucose are also reduced with bed rest, but the potential influence on glucose tolerance has not been investigated. Accordingly, the aim was to investigate whether bed rest-induced impairments in glucose tolerance are related to a concomitant reduction in plasma volume. This hypothesis was tested mechanistically by restoring plasma volume with albumin infusion after bed rest and parallel determination of glucose tolerance. Fifteen healthy volunteers (age 24 ± 3 yr, body mass index 23 ± 2 kg/m2, maximal oxygen uptake 44 ± 8 ml·min-1·kg-1; means ± SD) completed 4 days of strict bed rest. Glucose tolerance [oral glucose tolerance test (OGTT)] and plasma and blood volumes (carbon monoxide rebreathing) were assessed before and after 3 days of bed rest. On the fourth day of bed rest, plasma volume was restored by means of an albumin infusion prior to an OGTT. Plasma volume was reduced by 9.9 ± 3.0% on bed rest day 3 and area under the curve for OGTT was augmented by 55 ± 67%. However, no association (R2 = 0.09, P = 0.33) between these simultaneously occurring responses was found. While normalization of plasma volume by matched albumin administration (408 ± 104 ml) transiently decreased (P < 0.05) resting plasma glucose concentration (5.0 ± 0.4 to 4.8 ± 0.3 mmol/l), this did not restore glucose tolerance. Bed rest-induced alterations in dilution space may influence resting glucose values but do not affect area under the curve for OGTT." @default.
- W2519253780 created "2016-09-23" @default.
- W2519253780 creator A5009949348 @default.
- W2519253780 creator A5016811159 @default.
- W2519253780 creator A5022069943 @default.
- W2519253780 creator A5024551384 @default.
- W2519253780 creator A5035060479 @default.
- W2519253780 creator A5057408680 @default.
- W2519253780 creator A5062945642 @default.
- W2519253780 creator A5066850019 @default.
- W2519253780 date "2016-11-01" @default.
- W2519253780 modified "2023-10-16" @default.
- W2519253780 title "Effect of alterations in blood volume with bed rest on glucose tolerance" @default.
- W2519253780 cites W1515301967 @default.
- W2519253780 cites W1573048241 @default.
- W2519253780 cites W1868212978 @default.
- W2519253780 cites W1935533885 @default.
- W2519253780 cites W1969932276 @default.
- W2519253780 cites W1992547263 @default.
- W2519253780 cites W1992817995 @default.
- W2519253780 cites W1994130882 @default.
- W2519253780 cites W1996298369 @default.
- W2519253780 cites W1997279776 @default.
- W2519253780 cites W2006665808 @default.
- W2519253780 cites W2010200556 @default.
- W2519253780 cites W2043928078 @default.
- W2519253780 cites W2044379830 @default.
- W2519253780 cites W2048109379 @default.
- W2519253780 cites W2053627832 @default.
- W2519253780 cites W2066330579 @default.
- W2519253780 cites W2083805707 @default.
- W2519253780 cites W2088148829 @default.
- W2519253780 cites W2090899605 @default.
- W2519253780 cites W2093985390 @default.
- W2519253780 cites W2112086908 @default.
- W2519253780 cites W2113365379 @default.
- W2519253780 cites W2114710196 @default.
- W2519253780 cites W2116958794 @default.
- W2519253780 cites W2122953585 @default.
- W2519253780 cites W2123134297 @default.
- W2519253780 cites W2140621225 @default.
- W2519253780 cites W2143137123 @default.
- W2519253780 cites W2146877877 @default.
- W2519253780 cites W2205799810 @default.
- W2519253780 cites W2223289688 @default.
- W2519253780 cites W4296976539 @default.
- W2519253780 doi "https://doi.org/10.1152/japplphysiol.00624.2016" @default.
- W2519253780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27633742" @default.
- W2519253780 hasPublicationYear "2016" @default.
- W2519253780 type Work @default.
- W2519253780 sameAs 2519253780 @default.
- W2519253780 citedByCount "14" @default.
- W2519253780 countsByYear W25192537802017 @default.
- W2519253780 countsByYear W25192537802018 @default.
- W2519253780 countsByYear W25192537802019 @default.
- W2519253780 countsByYear W25192537802020 @default.
- W2519253780 countsByYear W25192537802021 @default.
- W2519253780 countsByYear W25192537802022 @default.
- W2519253780 crossrefType "journal-article" @default.
- W2519253780 hasAuthorship W2519253780A5009949348 @default.
- W2519253780 hasAuthorship W2519253780A5016811159 @default.
- W2519253780 hasAuthorship W2519253780A5022069943 @default.
- W2519253780 hasAuthorship W2519253780A5024551384 @default.
- W2519253780 hasAuthorship W2519253780A5035060479 @default.
- W2519253780 hasAuthorship W2519253780A5057408680 @default.
- W2519253780 hasAuthorship W2519253780A5062945642 @default.
- W2519253780 hasAuthorship W2519253780A5066850019 @default.
- W2519253780 hasBestOaLocation W25192537801 @default.
- W2519253780 hasConcept C126322002 @default.
- W2519253780 hasConcept C134018914 @default.
- W2519253780 hasConcept C185592680 @default.
- W2519253780 hasConcept C2776125364 @default.
- W2519253780 hasConcept C2776575606 @default.
- W2519253780 hasConcept C2777391703 @default.
- W2519253780 hasConcept C2777854218 @default.
- W2519253780 hasConcept C2779306644 @default.
- W2519253780 hasConcept C2780833929 @default.
- W2519253780 hasConcept C2991747820 @default.
- W2519253780 hasConcept C37557685 @default.
- W2519253780 hasConcept C71924100 @default.
- W2519253780 hasConceptScore W2519253780C126322002 @default.
- W2519253780 hasConceptScore W2519253780C134018914 @default.
- W2519253780 hasConceptScore W2519253780C185592680 @default.
- W2519253780 hasConceptScore W2519253780C2776125364 @default.
- W2519253780 hasConceptScore W2519253780C2776575606 @default.
- W2519253780 hasConceptScore W2519253780C2777391703 @default.
- W2519253780 hasConceptScore W2519253780C2777854218 @default.
- W2519253780 hasConceptScore W2519253780C2779306644 @default.
- W2519253780 hasConceptScore W2519253780C2780833929 @default.
- W2519253780 hasConceptScore W2519253780C2991747820 @default.
- W2519253780 hasConceptScore W2519253780C37557685 @default.
- W2519253780 hasConceptScore W2519253780C71924100 @default.
- W2519253780 hasIssue "5" @default.
- W2519253780 hasLocation W25192537801 @default.
- W2519253780 hasLocation W25192537802 @default.
- W2519253780 hasOpenAccess W2519253780 @default.
- W2519253780 hasPrimaryLocation W25192537801 @default.
- W2519253780 hasRelatedWork W1992838000 @default.