Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519307991> ?p ?o ?g. }
- W2519307991 endingPage "293" @default.
- W2519307991 startingPage "280" @default.
- W2519307991 abstract "Central nervous system (CNS) drug delivery is often hampered due to the insidious nature of the blood-brain barrier (BBB). Nose-to-brain delivery via olfactory pathways have become a target of attention for drug delivery due to bypassing of the BBB. The antioxidant properties of phytochemicals make them promising as CNS active agents but possess poor water solubility and limited BBB penetration. The primary aim of this study was the development of mesoporous silica nanoparticles (MSNs) loaded with the poorly water-soluble phytochemicals curcumin and chrysin which could be utilised for nose-to-brain delivery. We formulated spherical MSNP using a templating approach resulting in ∼220 nm particles with a high surface porosity. Curcumin and chrysin were successfully loaded into MSNP and confirmed through Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC approaches with a loading of 11–14% for curcumin and chrysin. Release was pH dependant with curcumin demonstrating increased chemical stability at a lower pH (5.5) with a release of 53.2% ± 2.2% over 24 h and 9.4 ± 0.6% for chrysin. MSNP were demonstrated to be non-toxic to olfactory neuroblastoma cells OBGF400, with chrysin (100 μM) demonstrating a decrease in cell viability to 58.2 ± 8.5% and curcumin an IC50 of 33 ± 0.18 μM. Furthermore confocal microscopy demonstrated nanoparticles of <500 nm were able to accumulate within cells with FITC-loaded MSNP showing membrane localised and cytoplasmic accumulation following a 2 h incubation. MSNP are useful carriers for poorly soluble phytochemicals and provide a novel vehicle to target and deliver drugs into the CNS and bypass the BBB through olfactory drug delivery." @default.
- W2519307991 created "2016-09-23" @default.
- W2519307991 creator A5029805964 @default.
- W2519307991 creator A5034312186 @default.
- W2519307991 creator A5065715517 @default.
- W2519307991 date "2016-11-01" @default.
- W2519307991 modified "2023-09-30" @default.
- W2519307991 title "Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery" @default.
- W2519307991 cites W1734725029 @default.
- W2519307991 cites W1774764329 @default.
- W2519307991 cites W1794474282 @default.
- W2519307991 cites W1886950258 @default.
- W2519307991 cites W1895993106 @default.
- W2519307991 cites W1900968643 @default.
- W2519307991 cites W1923719421 @default.
- W2519307991 cites W1966805482 @default.
- W2519307991 cites W1967077419 @default.
- W2519307991 cites W1971891111 @default.
- W2519307991 cites W1974129665 @default.
- W2519307991 cites W1974571230 @default.
- W2519307991 cites W1976219141 @default.
- W2519307991 cites W1978274834 @default.
- W2519307991 cites W1979250589 @default.
- W2519307991 cites W1980884243 @default.
- W2519307991 cites W1982262593 @default.
- W2519307991 cites W1982397837 @default.
- W2519307991 cites W1982826081 @default.
- W2519307991 cites W1983444549 @default.
- W2519307991 cites W1984783825 @default.
- W2519307991 cites W1998271063 @default.
- W2519307991 cites W1999489972 @default.
- W2519307991 cites W2000424893 @default.
- W2519307991 cites W2001955314 @default.
- W2519307991 cites W2006288240 @default.
- W2519307991 cites W2007504603 @default.
- W2519307991 cites W2007790188 @default.
- W2519307991 cites W2009288654 @default.
- W2519307991 cites W2010318800 @default.
- W2519307991 cites W2010415507 @default.
- W2519307991 cites W2010655741 @default.
- W2519307991 cites W2011254969 @default.
- W2519307991 cites W2015704490 @default.
- W2519307991 cites W2019350044 @default.
- W2519307991 cites W2023536393 @default.
- W2519307991 cites W2024334841 @default.
- W2519307991 cites W2025198562 @default.
- W2519307991 cites W2025539378 @default.
- W2519307991 cites W2038371739 @default.
- W2519307991 cites W2038459954 @default.
- W2519307991 cites W2042602209 @default.
- W2519307991 cites W2044890756 @default.
- W2519307991 cites W2045309263 @default.
- W2519307991 cites W2046005844 @default.
- W2519307991 cites W2051575873 @default.
- W2519307991 cites W2059314981 @default.
- W2519307991 cites W2062523063 @default.
- W2519307991 cites W2062530724 @default.
- W2519307991 cites W2063950674 @default.
- W2519307991 cites W2065566358 @default.
- W2519307991 cites W2065752658 @default.
- W2519307991 cites W2066421513 @default.
- W2519307991 cites W2068601472 @default.
- W2519307991 cites W2069060532 @default.
- W2519307991 cites W2069506489 @default.
- W2519307991 cites W2069836641 @default.
- W2519307991 cites W2069954940 @default.
- W2519307991 cites W2070356285 @default.
- W2519307991 cites W2072175441 @default.
- W2519307991 cites W2080962368 @default.
- W2519307991 cites W2081095452 @default.
- W2519307991 cites W2082023233 @default.
- W2519307991 cites W2082729702 @default.
- W2519307991 cites W2088496138 @default.
- W2519307991 cites W2090283144 @default.
- W2519307991 cites W2101099825 @default.
- W2519307991 cites W2101193630 @default.
- W2519307991 cites W2103699988 @default.
- W2519307991 cites W2106075109 @default.
- W2519307991 cites W2106536537 @default.
- W2519307991 cites W2107423984 @default.
- W2519307991 cites W2113928060 @default.
- W2519307991 cites W2114179943 @default.
- W2519307991 cites W2117326659 @default.
- W2519307991 cites W2121740413 @default.
- W2519307991 cites W2124158735 @default.
- W2519307991 cites W2124865710 @default.
- W2519307991 cites W2127256052 @default.
- W2519307991 cites W2127343735 @default.
- W2519307991 cites W2129128202 @default.
- W2519307991 cites W2135222397 @default.
- W2519307991 cites W2138122919 @default.
- W2519307991 cites W2145562853 @default.
- W2519307991 cites W2146974279 @default.
- W2519307991 cites W2148146955 @default.
- W2519307991 cites W2152752812 @default.
- W2519307991 cites W2155118487 @default.
- W2519307991 cites W2158138220 @default.
- W2519307991 cites W2162268834 @default.