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• W2519323265 startingPage "31" @default.
• W2519323265 abstract "In the past decade the introduction of targeted therapies has dramatically transformed the landscape of treatment for chronic lymphocytic leukemia (CLL). Whether this new therapeutic scenario will modify the current prevalence statistics and natural history of autoimmune cytopenias complicating CLL is still a matter of debate. Here we present a comprehensive review of the literature on this topic, with special emphasis on the incidence of autoimmune hemolytic anemia (AIHA). The potential to induce autoimmune cytopenia has been studied mostly with ibrutinib, a first- in-class bruton kinase (BTK) inhibitor, licensed for the treatment of relapsed/refractory high-risk CLL. Recent observations suggest that emergent AIHA occurring during therapy with ibrutinib is more an expression of CLL activity than an ibrutinib-mediated process. Since available information on AIHA occurring during and after therapy with small-molecule kinase inhibitors relies mainly on data collected from clinical trials, a close post- marketing surveillance is mandatory in order to improve our understanding of this topic." @default.
• W2519323265 created "2016-09-23" @default.
• W2519323265 creator A5055759686 @default.
• W2519323265 creator A5061896020 @default.
• W2519323265 date "2016-11-01" @default.
• W2519323265 modified "2023-10-18" @default.
• W2519323265 title "Autoimmune hemolytic anemia (AIHA) associated with chronic lymphocytic leukemia in the current era of targeted therapy" @default.
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• W2519323265 doi "https://doi.org/10.1016/j.leukres.2016.09.002" @default.
• W2519323265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27657651" @default.
• W2519323265 hasPublicationYear "2016" @default.
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