Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519325934> ?p ?o ?g. }
- W2519325934 endingPage "e892" @default.
- W2519325934 startingPage "e892" @default.
- W2519325934 abstract "Wnts-related signaling pathways have been reported to play roles in the pathogenesis of stress-induced depression-like behaviors. However, there is relatively few direct evidence to indicate the effect of Wnt ligands on this process. Here, we investigated the role of Wnts in mediating chronic restraint stress (CRS)-induced depression-like behaviors. We found that CRS induced a significant decrease in the expression of Wnt2 and Wnt3 in the ventral hippocampus (VH) but not in the dorsal hippocampus. Knocking down Wnt2 or Wnt3 in the VH led to impaired Wnt/β-catenin signaling, neurogenesis deficits and depression-like behaviors. In contrast, overexpression of Wnt2 or Wnt3 reversed CRS-induced depression-like behaviors. Moreover, Wnt2 and Wnt3 activated cAMP response element-binding protein (CREB) and there was CREB-dependent positive feedback between Wnt2 and Wnt3. Finally, fluoxetine treatment increased Wnt2 and Wnt3 levels in the VH and knocking down Wnt2 or Wnt3 abolished the antidepressant effect of fluoxetine. Taken together, our study indicates essential roles for Wnt2 and Wnt3 in CRS-induced depression-like behaviors and antidepressant." @default.
- W2519325934 created "2016-09-23" @default.
- W2519325934 creator A5028138280 @default.
- W2519325934 creator A5034034468 @default.
- W2519325934 creator A5039670017 @default.
- W2519325934 creator A5056207671 @default.
- W2519325934 creator A5060424374 @default.
- W2519325934 creator A5067536950 @default.
- W2519325934 creator A5069913800 @default.
- W2519325934 creator A5077911925 @default.
- W2519325934 date "2016-09-13" @default.
- W2519325934 modified "2023-10-12" @default.
- W2519325934 title "The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors" @default.
- W2519325934 cites W1516186123 @default.
- W2519325934 cites W1842826350 @default.
- W2519325934 cites W1963600261 @default.
- W2519325934 cites W1963745928 @default.
- W2519325934 cites W1965856326 @default.
- W2519325934 cites W1968570162 @default.
- W2519325934 cites W1968900418 @default.
- W2519325934 cites W1970771603 @default.
- W2519325934 cites W1971655394 @default.
- W2519325934 cites W1977452893 @default.
- W2519325934 cites W1978727260 @default.
- W2519325934 cites W1984977814 @default.
- W2519325934 cites W1988181440 @default.
- W2519325934 cites W1988375440 @default.
- W2519325934 cites W1990800915 @default.
- W2519325934 cites W1993796910 @default.
- W2519325934 cites W1994584258 @default.
- W2519325934 cites W1995880620 @default.
- W2519325934 cites W1996251825 @default.
- W2519325934 cites W1998977808 @default.
- W2519325934 cites W2003070777 @default.
- W2519325934 cites W2003762546 @default.
- W2519325934 cites W2006419043 @default.
- W2519325934 cites W2008565294 @default.
- W2519325934 cites W2012762570 @default.
- W2519325934 cites W2022948552 @default.
- W2519325934 cites W2023659636 @default.
- W2519325934 cites W2033456614 @default.
- W2519325934 cites W2035361482 @default.
- W2519325934 cites W2038459152 @default.
- W2519325934 cites W2039644413 @default.
- W2519325934 cites W2045571228 @default.
- W2519325934 cites W2046396569 @default.
- W2519325934 cites W2046960533 @default.
- W2519325934 cites W2051005796 @default.
- W2519325934 cites W2054500214 @default.
- W2519325934 cites W2057972230 @default.
- W2519325934 cites W2060918456 @default.
- W2519325934 cites W2060952910 @default.
- W2519325934 cites W2061600075 @default.
- W2519325934 cites W2061711185 @default.
- W2519325934 cites W2066703719 @default.
- W2519325934 cites W2071371666 @default.
- W2519325934 cites W2071420631 @default.
- W2519325934 cites W2073477928 @default.
- W2519325934 cites W2074815848 @default.
- W2519325934 cites W2076645897 @default.
- W2519325934 cites W2078058274 @default.
- W2519325934 cites W2078186303 @default.
- W2519325934 cites W2089204174 @default.
- W2519325934 cites W2089299823 @default.
- W2519325934 cites W2091805482 @default.
- W2519325934 cites W2092235051 @default.
- W2519325934 cites W2093765498 @default.
- W2519325934 cites W2094375874 @default.
- W2519325934 cites W2100519706 @default.
- W2519325934 cites W2118826874 @default.
- W2519325934 cites W2119284420 @default.
- W2519325934 cites W2133627256 @default.
- W2519325934 cites W2137075274 @default.
- W2519325934 cites W2141041835 @default.
- W2519325934 cites W2143629083 @default.
- W2519325934 cites W2148239264 @default.
- W2519325934 cites W2154641154 @default.
- W2519325934 cites W2163694230 @default.
- W2519325934 cites W2164012002 @default.
- W2519325934 cites W2168956071 @default.
- W2519325934 cites W337699631 @default.
- W2519325934 doi "https://doi.org/10.1038/tp.2016.122" @default.
- W2519325934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5048193" @default.
- W2519325934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27622936" @default.
- W2519325934 hasPublicationYear "2016" @default.
- W2519325934 type Work @default.
- W2519325934 sameAs 2519325934 @default.
- W2519325934 citedByCount "39" @default.
- W2519325934 countsByYear W25193259342017 @default.
- W2519325934 countsByYear W25193259342018 @default.
- W2519325934 countsByYear W25193259342019 @default.
- W2519325934 countsByYear W25193259342020 @default.
- W2519325934 countsByYear W25193259342021 @default.
- W2519325934 countsByYear W25193259342022 @default.
- W2519325934 countsByYear W25193259342023 @default.
- W2519325934 crossrefType "journal-article" @default.
- W2519325934 hasAuthorship W2519325934A5028138280 @default.
- W2519325934 hasAuthorship W2519325934A5034034468 @default.