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• W2519329600 abstract "Crimean-Congo hemorrhagic fever (CCHF) is an acute tick-borne viral disease transmitted to humans by Hyalomma ticks or by direct contact with the blood of infected humans or domestic animals. In certain areas of the world, including Africa, Asia, South East Europe and Middle East, sporadic cases or outbreaks of CCHF have been reported. During the last six-year period from 2003 to 2009, CCHF has also occurred endemically in Turkey, particularly during spring and summer, with a case-fatality rate of approximately 5%. The disease is characterized by acute fever, nausea, vomiting, headache, myalgia, elevated liver enzymes and hemorrhagic manifestations ranging from mucocutaneous bleeding to life-threatening massive hemorrhage with disseminated intravascular coagulation (DIC) and hemophagocytosis. As with other viral hemorrhagic diseases, activation of lymphocytes, monocytes, macrophages and oversecretion of cytokines play a pivotal role in the pathogenesis and prognosis of CCHF. Recently an increasing number of publications on CCHF have been emerging in the literature, majority of which have been written by infection specialists. In this article, recent literature on CCHF has been reviewed, with particular emphasis on hematological manifestations, pathogenesis and therapeutic approaches in CCHF from the hematologist's point of view. Kırım-Kongo kanamalı ateşi (KKKA) insanlara Hiyalom keneleri aracılığıyla ya da enfekte veya evcil hayvanların kanlarına doğrudan temas aracılığıyla insanlara geçen akut bir kene yoluyla bulaşan viral hastalıktır. Afrika, Asya, Güney Doğu Avrupa ve Orta Doğu da dahil dünyanın belirli bölgelerinde KKKA’ya ait sporadik vakalar yada salgınlar rapor edilmiştir. 2003’ten 2009 yılına kadar geçen altı yıllık süre boyunca özellikle bahar ve yaz aylarında yaklaşık %5’lik bir vaka-ölüm oranıyla endemik olarak Türkiye'de de görülmüştür. Hastalık akut ateş, bulantı, kusma, baş ağrısı, miyalji, karaciğer enzimlerinin yükselmesi ve mukokütanöz kanamadan yaşamı tehdit eden yaygın damariçi intravasküler koagülasyon (DIC) ve hemofagositozla birlikte masif kanamalara kadar bir yelpazede hemorajik manifestasyonlar ile karakterizedir. Diğer viral hemorajik hastalıklarda olduğu gibi, lenfositlerin, monositlerin, makrofajların aktivasyonu ve sitokinlerin aşırı sekresyonu KKKA’nın patojenez ve prognozunda kilit bir rol oynar. Son zamanlarda literatürde KKKA ile ilgili olarak daha çok enfeksiyon uzmanları tarafından yazılan yayınlarda artma olduğu görülmektedir. Bu makalede hematologun bakış açısıyla özellikle KKKA’daki hematolojik belirtiler, patojenez ve tedavi yaklaşımları üzerine vurgu yapılarak KKKA hakkında yayınlar gözden geçirilmiştir." @default.
• W2519329600 created "2016-09-23" @default.
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• W2519329600 date "2009-12-05" @default.
• W2519329600 modified "2023-10-16" @default.
• W2519329600 title "Hematological aspects of Crimean-Congo hemorrhagic fever." @default.
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