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- W2519360018 abstract "Coronary thrombolysis or percutaneous transluminal coronary recanalization (PTCR) has recently been established as a treatment of acute myocardial infarction (AMI). This study was performed to elucidate the changes in plasma levels of β-thromboglobulin (β-TG), fibrinopeptides and prostaglandins before and after the PTCR. Twenty-six AMI patients within 6 hours after its onset, 53±12.1 (SD) years of age were subjected for the PTCR using with urokinase (680, 000±124, 000 IU). Eleven patients among 26 undergone PTCR were selected for the determination of plasma levels of β-TG, thromboxane B2 (TXB2), 6-keto-PGF1α, fibrinopeptide A (FpA) and FpBβ 15-42 before and serially after PTCR.Successful recanalization was obtained in 18 out of 26 cases (69.2%). β-TG was elevated both in successful and unsuccessful cases suggesting platelet activation in AMI. Those who achieved good recanalization demonstrated a sharp rise of β-TG probably due to wash-out phenomenon shortly after the recanalization. β-TG returned to the normal range within 1-7 days (Fig. 1) TXB2 was increased in both groups, higher in the recanalized group and gradually returned to the normal range in several days. Two out of 5 recanalized cases demonstrated wash-out phenomenon. 6-keto-PGF1α levels were also increased in AMI which became normalized in a day. FpA was increased in both groups in the acute stage of AMI suggesting the hypercoagulable state and gradually decreased to the normal range. FpBβ made a peak at the termination of PTCR, higher in the recanalized cases suggesting better fibrinolysis, and rapidly decreased in a day. A typical case of successful PTCR was shown in Figure 2. Marked rises in β-TG and TXB2 shortly after PTCR may indicate recanalization of the obstructed coronary artery." @default.
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- W2519360018 date "1984-01-01" @default.
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- W2519360018 doi "https://doi.org/10.2491/jjsth1970.15.427" @default.
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