Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519377777> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2519377777 abstract "The present work deals with design, synthesis, mechanistic study and biological evaluation of novel, diverse compounds as potential inhibitors of cyclin-dependent kinase 2 (CDK2). Multi-complex-based method has been suggested to generate a comprehensive pharmacophore map of cyclin-dependent kinase 2 (CDK2) based on a collection of 13 crystal structures of human CDK2 inhibitor complex. The proposed chromeno [4',3':4,5] N pyrido [2,3-d] pyrimidine-1,7-dione derivatives were prepared via a multicomponent reaction of 6-aminothiouracil with salicylic aldehyde and acetylacetic ester. The elucidation of the reaction mechanism was investigated and was confirmed by synthetic and spectroscopic methods. All the newly synthesized compounds were tested as CDK2, as antitumor agents and all of them were found to be active." @default.
- W2519377777 created "2016-09-23" @default.
- W2519377777 creator A5047254533 @default.
- W2519377777 date "2016-01-01" @default.
- W2519377777 modified "2023-09-27" @default.
- W2519377777 title "A Multi-Component Reaction to 6-Aminothiouracils: Synthesis, Mechanistic Study and Antitumor Activity" @default.
- W2519377777 cites W1545201063 @default.
- W2519377777 cites W1971140803 @default.
- W2519377777 cites W1973596168 @default.
- W2519377777 cites W1975732065 @default.
- W2519377777 cites W1977744458 @default.
- W2519377777 cites W1978985435 @default.
- W2519377777 cites W1985188210 @default.
- W2519377777 cites W1988968220 @default.
- W2519377777 cites W1989834919 @default.
- W2519377777 cites W1998470981 @default.
- W2519377777 cites W2009445851 @default.
- W2519377777 cites W2023613726 @default.
- W2519377777 cites W2023745448 @default.
- W2519377777 cites W2033751505 @default.
- W2519377777 cites W2044540162 @default.
- W2519377777 cites W2079191076 @default.
- W2519377777 cites W2085593164 @default.
- W2519377777 cites W2094423289 @default.
- W2519377777 cites W2095909899 @default.
- W2519377777 cites W2097981550 @default.
- W2519377777 cites W2109689528 @default.
- W2519377777 cites W2110630328 @default.
- W2519377777 cites W2124330168 @default.
- W2519377777 cites W2129729029 @default.
- W2519377777 cites W2135129680 @default.
- W2519377777 cites W2138697269 @default.
- W2519377777 cites W2142540964 @default.
- W2519377777 cites W2160668192 @default.
- W2519377777 cites W2168753948 @default.
- W2519377777 cites W2312672484 @default.
- W2519377777 cites W2470711347 @default.
- W2519377777 cites W2471616542 @default.
- W2519377777 cites W2903660347 @default.
- W2519377777 cites W2949985550 @default.
- W2519377777 cites W2952303572 @default.
- W2519377777 cites W97735725 @default.
- W2519377777 doi "https://doi.org/10.4172/2167-7700.1000212" @default.
- W2519377777 hasPublicationYear "2016" @default.
- W2519377777 type Work @default.
- W2519377777 sameAs 2519377777 @default.
- W2519377777 citedByCount "1" @default.
- W2519377777 countsByYear W25193777772021 @default.
- W2519377777 crossrefType "journal-article" @default.
- W2519377777 hasAuthorship W2519377777A5047254533 @default.
- W2519377777 hasConcept C161790260 @default.
- W2519377777 hasConcept C184235292 @default.
- W2519377777 hasConcept C185592680 @default.
- W2519377777 hasConcept C21951064 @default.
- W2519377777 hasConcept C2779321679 @default.
- W2519377777 hasConcept C2779825165 @default.
- W2519377777 hasConcept C55493867 @default.
- W2519377777 hasConcept C56173144 @default.
- W2519377777 hasConcept C71240020 @default.
- W2519377777 hasConcept C82495950 @default.
- W2519377777 hasConcept C97029542 @default.
- W2519377777 hasConceptScore W2519377777C161790260 @default.
- W2519377777 hasConceptScore W2519377777C184235292 @default.
- W2519377777 hasConceptScore W2519377777C185592680 @default.
- W2519377777 hasConceptScore W2519377777C21951064 @default.
- W2519377777 hasConceptScore W2519377777C2779321679 @default.
- W2519377777 hasConceptScore W2519377777C2779825165 @default.
- W2519377777 hasConceptScore W2519377777C55493867 @default.
- W2519377777 hasConceptScore W2519377777C56173144 @default.
- W2519377777 hasConceptScore W2519377777C71240020 @default.
- W2519377777 hasConceptScore W2519377777C82495950 @default.
- W2519377777 hasConceptScore W2519377777C97029542 @default.
- W2519377777 hasLocation W25193777771 @default.
- W2519377777 hasOpenAccess W2519377777 @default.
- W2519377777 hasPrimaryLocation W25193777771 @default.
- W2519377777 hasRelatedWork W186817547 @default.
- W2519377777 hasRelatedWork W1974397056 @default.
- W2519377777 hasRelatedWork W2014605200 @default.
- W2519377777 hasRelatedWork W2023654436 @default.
- W2519377777 hasRelatedWork W2041871746 @default.
- W2519377777 hasRelatedWork W2060678503 @default.
- W2519377777 hasRelatedWork W2076772021 @default.
- W2519377777 hasRelatedWork W2082107959 @default.
- W2519377777 hasRelatedWork W2083744576 @default.
- W2519377777 hasRelatedWork W2085126121 @default.
- W2519377777 hasRelatedWork W2174176740 @default.
- W2519377777 hasRelatedWork W2211381740 @default.
- W2519377777 hasRelatedWork W2351225541 @default.
- W2519377777 hasRelatedWork W2470179570 @default.
- W2519377777 hasRelatedWork W2514894852 @default.
- W2519377777 hasRelatedWork W2559709307 @default.
- W2519377777 hasRelatedWork W2567232573 @default.
- W2519377777 hasRelatedWork W2921227021 @default.
- W2519377777 hasRelatedWork W3046530508 @default.
- W2519377777 hasRelatedWork W3189110082 @default.
- W2519377777 isParatext "false" @default.
- W2519377777 isRetracted "false" @default.
- W2519377777 magId "2519377777" @default.
- W2519377777 workType "article" @default.