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• W2519492057 abstract "In this study, a phytochemical and biological investigation on five South Brazilian Hypericum species ( Hypericum caprifoliatum , Hypericum carinatum , Hypericum connatum , Hypericum myrianthum , and Hypericum polyanthemum ) was carried out. The phloroglucinol‐enriched fractions (PEF) of the flowering aerial parts were analyzed by high‐performance liquid chromatography for the content of uliginosin A ( 1 ), japonicin A ( 2 ), uliginosin B ( 3 ), hyperbrasilol B ( 4 ), and the three benzopyrans, that is, 6‐isobutyryl‐5,7‐dimethoxy‐2,2‐dimethyl‐benzopyran (HP1) ( 5 ), 7‐hydroxy‐6‐isobutyryl‐5‐methoxy‐2,2‐dimethyl‐benzopyran (HP2) ( 6 ), and 5‐hydroxy‐6‐isobutyryl‐7‐methoxy‐2,2‐dimethyl‐benzopyran (HP3) ( 7 ). After chemical characterization, the PEF were assayed for cell proliferation on human keratinocyte cell line by MTT. The H. carinatum and H . polyanthemum PEF demonstrated better results with an increase in cell proliferation (138.7% and 120.6%, respectively). The cell counting and Ki‐67 assay with H . carinatum PEF confirmed the MTT results. The cell cycle distribution indicates an increase in the cells at S and G2/M phases, which is indicative of proliferation induction. In summary, the results indicate an induction of HaCaT proliferation by the treatment with H . carinatum PEF (at 10 and 15 µg/mL), suggesting a possible use as wound healing agent. Copyright © 2016 John Wiley & Sons, Ltd." @default.
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• W2519492057 date "2016-09-13" @default.
• W2519492057 modified "2023-10-10" @default.
• W2519492057 title "Characterization of Phloroglucinol-enriched Fractions of Brazilian<i>Hypericum</i>Species and Evaluation of Their Effect on Human Keratinocytes Proliferation" @default.
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• W2519492057 doi "https://doi.org/10.1002/ptr.5727" @default.
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