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- W2519492992 abstract "the dyes; (3) Appropriate description for the spatial distribution of the fluoro-phore by fast accessible volume (AV) simulations [2] to determine the dye po-sitions relative to the biomolecule; (4) Search for possible structures viaa FRET positioning system using a spring-network algorithm. Possible struc-tures are generated either by a model-based approach with rigid body dockingor model free by selecting suitable models from a huge structure library; (5)Docking is repeated many times to find all possible arrangements and assurethe completeness of generated structural ensemble; (6) The obtained modelsare ranked according to their violation of FRET constraints and steric clashes.Then they are assigned to clusters of related structural organization in order tojudge the uniqueness of structural models; (7) The precision (RMSD) of thestructure models is determined using a bootstrapping procedure. We demon-strate the accuracy of high-precision (hp) FRET in two experiments - determi-nation of the DNA position in HIV-1 reverse transcriptase:primer/templatecomplexes and arrangement of a primer/template DNA bound by HIV-1 re-verse transcriptase and analysis of the internal structural heterogeneity ofhuman guanylate binding protein 1 (hGBP1). These studies show that hpFRETstudies are valuable tool to complement the structure information obtainedby classical methods.[1] Sisamakis, E., et al.; Methods in Enzymology 475, 455-514 (2010).[2] Sindbert, S., et al.; J. Am. Chem. Soc. 133, 2463-2480 (2011)." @default.
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- W2519492992 date "2012-01-01" @default.
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- W2519492992 title "Platform: Interfacial Protein-Lipid Interactions I" @default.
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