Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519508001> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2519508001 endingPage "189" @default.
- W2519508001 startingPage "183" @default.
- W2519508001 abstract "The kidney disease improving global outcomes (KDIGO) clinical practice guidelines for acute kidney injury (AKI) has endorsed the widely held belief that female gender is a risk factor for aminoglycoside-associated nephrotoxicity (AAN). In contrast, female gender is protective in animal models. In light of this dichotomy, we sought to explore this relationship in greater detail.We performed a meta-analysis of studies published between 1978 and 2015 which examined aminoglycoside nephrotoxicity and provided gender-specific data.24 studies were identified that provided univariate gender-specific data. The incidence of AAN did not differ between the sexes (odds ratio (OR) for females vs. males 1.00 (0.81, 1.22), p = 0.97, n = 5,980). Twelve studies utilized logistic regression analysis with gender as a covariate. Meta-analysis of the 5 studies that utilized multivariate analysis and reported gender-specific OR found no effect of gender on the risk of AAN (OR 0.99 (0.58, 1.69), p = 0.96, n = 2,994). Similarly, gender was not an independent risk factor for AAN in the remaining 7 studies that utilized multivariate analysis with gender as a covariate but failed to report gender-specific OR (n = 1,636).Our meta-analysis contradicts the generally held consensus that female gender is an independent risk factor for the development of AAN. Our findings may have much wider implications insofar as AAN cannot be used as an example to support the conclusion of the KDIGO Clinical Practice Guidelines that female gender is an independent risk factor for AKI. ." @default.
- W2519508001 created "2016-09-23" @default.
- W2519508001 creator A5016404477 @default.
- W2519508001 creator A5082775963 @default.
- W2519508001 date "2016-10-01" @default.
- W2519508001 modified "2023-10-14" @default.
- W2519508001 title "The effect of gender on aminoglycoside-associated nephrotoxicity" @default.
- W2519508001 doi "https://doi.org/10.5414/cn108927" @default.
- W2519508001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27616758" @default.
- W2519508001 hasPublicationYear "2016" @default.
- W2519508001 type Work @default.
- W2519508001 sameAs 2519508001 @default.
- W2519508001 citedByCount "14" @default.
- W2519508001 countsByYear W25195080012017 @default.
- W2519508001 countsByYear W25195080012018 @default.
- W2519508001 countsByYear W25195080012019 @default.
- W2519508001 countsByYear W25195080012021 @default.
- W2519508001 countsByYear W25195080012022 @default.
- W2519508001 countsByYear W25195080012023 @default.
- W2519508001 crossrefType "journal-article" @default.
- W2519508001 hasAuthorship W2519508001A5016404477 @default.
- W2519508001 hasAuthorship W2519508001A5082775963 @default.
- W2519508001 hasConcept C105795698 @default.
- W2519508001 hasConcept C119043178 @default.
- W2519508001 hasConcept C126189478 @default.
- W2519508001 hasConcept C126322002 @default.
- W2519508001 hasConcept C144301174 @default.
- W2519508001 hasConcept C151956035 @default.
- W2519508001 hasConcept C156957248 @default.
- W2519508001 hasConcept C2778653478 @default.
- W2519508001 hasConcept C2780091579 @default.
- W2519508001 hasConcept C33923547 @default.
- W2519508001 hasConcept C38180746 @default.
- W2519508001 hasConcept C50440223 @default.
- W2519508001 hasConcept C71924100 @default.
- W2519508001 hasConcept C97928714 @default.
- W2519508001 hasConceptScore W2519508001C105795698 @default.
- W2519508001 hasConceptScore W2519508001C119043178 @default.
- W2519508001 hasConceptScore W2519508001C126189478 @default.
- W2519508001 hasConceptScore W2519508001C126322002 @default.
- W2519508001 hasConceptScore W2519508001C144301174 @default.
- W2519508001 hasConceptScore W2519508001C151956035 @default.
- W2519508001 hasConceptScore W2519508001C156957248 @default.
- W2519508001 hasConceptScore W2519508001C2778653478 @default.
- W2519508001 hasConceptScore W2519508001C2780091579 @default.
- W2519508001 hasConceptScore W2519508001C33923547 @default.
- W2519508001 hasConceptScore W2519508001C38180746 @default.
- W2519508001 hasConceptScore W2519508001C50440223 @default.
- W2519508001 hasConceptScore W2519508001C71924100 @default.
- W2519508001 hasConceptScore W2519508001C97928714 @default.
- W2519508001 hasIssue "10" @default.
- W2519508001 hasLocation W25195080011 @default.
- W2519508001 hasLocation W25195080012 @default.
- W2519508001 hasOpenAccess W2519508001 @default.
- W2519508001 hasPrimaryLocation W25195080011 @default.
- W2519508001 hasRelatedWork W2034204715 @default.
- W2519508001 hasRelatedWork W2072961655 @default.
- W2519508001 hasRelatedWork W2164301666 @default.
- W2519508001 hasRelatedWork W2349419009 @default.
- W2519508001 hasRelatedWork W2389082831 @default.
- W2519508001 hasRelatedWork W2411462715 @default.
- W2519508001 hasRelatedWork W2520493033 @default.
- W2519508001 hasRelatedWork W3021932827 @default.
- W2519508001 hasRelatedWork W4232748760 @default.
- W2519508001 hasRelatedWork W4367041918 @default.
- W2519508001 hasVolume "86" @default.
- W2519508001 isParatext "false" @default.
- W2519508001 isRetracted "false" @default.
- W2519508001 magId "2519508001" @default.
- W2519508001 workType "article" @default.