Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519544049> ?p ?o ?g. }
- W2519544049 endingPage "1319" @default.
- W2519544049 startingPage "1309" @default.
- W2519544049 abstract "Objectives The lack of specific biochemical markers is a major drawback for the diagnosis of autoimmune pancreatitis (AIP). The aims were to characterize the autoantibody profiles in AIP and pancreatic ductal adenocarcinoma (PDAC) and to identify circulating autoantibodies that could be diagnostic markers differentiating PDAC and the AIP subtypes. Methods Tissue lysates obtained from the resected pancreas of patients with AIP and patients with PDAC were separated by 2-dimensional polyacrylamide gel electrophoresis subsequently immunoblotted with autologous sera. The immunoreactive spots were subjected to nanoscale liquid chromatography–electrospray ionization tandem mass spectrometry to identify serum autoantibodies to tissue-derived autoantigens associated with AIP and PDAC. Autoantibody concentrations for selected autoantigens were assessed by enzyme-linked immunosorbent assays. Results A total of 115 immunoreactive spots were identified by 2-dimensional polyacrylamide gel electrophoresis/immunobloting. Nanoscale liquid chromatography–electrospray ionization tandem mass spectrometry–based analysis revealed 68 autoantigens in AIP, 26 in PDAC, and 21 present in both diseases. Assessment of 13 selected AIP autoantibody serum levels revealed that 7 of them had significantly higher titers in AIP versus PDAC. IgG-directed against transaldolase could significantly differentiate between the 2 AIP subtypes. Conclusions The novel panel of AIP autoantibodies is promising to supplement the predictive tests for AIP of the currently known autoantigens and represent a basis for a combined blood test to differentiate AIP from PDAC in the future." @default.
- W2519544049 created "2016-09-23" @default.
- W2519544049 creator A5008903402 @default.
- W2519544049 creator A5049272282 @default.
- W2519544049 creator A5061652492 @default.
- W2519544049 creator A5067125554 @default.
- W2519544049 creator A5073565228 @default.
- W2519544049 creator A5076617999 @default.
- W2519544049 creator A5080981497 @default.
- W2519544049 creator A5083171620 @default.
- W2519544049 creator A5083391067 @default.
- W2519544049 date "2016-10-01" @default.
- W2519544049 modified "2023-10-17" @default.
- W2519544049 title "Identification of Novel Serum Autoantibodies for Differential Diagnosis of Autoimmune Pancreatitis and Pancreatic Ductal Adenocarcinoma" @default.
- W2519544049 cites W1538852229 @default.
- W2519544049 cites W1633888023 @default.
- W2519544049 cites W1789330480 @default.
- W2519544049 cites W1965679523 @default.
- W2519544049 cites W1966875921 @default.
- W2519544049 cites W1967906245 @default.
- W2519544049 cites W1969615927 @default.
- W2519544049 cites W1969965692 @default.
- W2519544049 cites W1972219003 @default.
- W2519544049 cites W1975970761 @default.
- W2519544049 cites W1977737319 @default.
- W2519544049 cites W1981373279 @default.
- W2519544049 cites W1982055449 @default.
- W2519544049 cites W1988026983 @default.
- W2519544049 cites W1993556199 @default.
- W2519544049 cites W1994675456 @default.
- W2519544049 cites W2000690365 @default.
- W2519544049 cites W2006986579 @default.
- W2519544049 cites W2008692337 @default.
- W2519544049 cites W2010764206 @default.
- W2519544049 cites W2019256148 @default.
- W2519544049 cites W2024490058 @default.
- W2519544049 cites W2031477993 @default.
- W2519544049 cites W2045245861 @default.
- W2519544049 cites W2046306972 @default.
- W2519544049 cites W2046662034 @default.
- W2519544049 cites W2056248535 @default.
- W2519544049 cites W2071958740 @default.
- W2519544049 cites W2072162133 @default.
- W2519544049 cites W2081330562 @default.
- W2519544049 cites W2084374360 @default.
- W2519544049 cites W2088333045 @default.
- W2519544049 cites W2089281427 @default.
- W2519544049 cites W2090330749 @default.
- W2519544049 cites W2101019713 @default.
- W2519544049 cites W2110343119 @default.
- W2519544049 cites W2112039471 @default.
- W2519544049 cites W2116556152 @default.
- W2519544049 cites W2117894829 @default.
- W2519544049 cites W2118509928 @default.
- W2519544049 cites W2122758490 @default.
- W2519544049 cites W2124562061 @default.
- W2519544049 cites W2124884934 @default.
- W2519544049 cites W2127659736 @default.
- W2519544049 cites W2130600160 @default.
- W2519544049 cites W2137132418 @default.
- W2519544049 cites W2140483523 @default.
- W2519544049 cites W2147311414 @default.
- W2519544049 cites W2159757085 @default.
- W2519544049 cites W2161327111 @default.
- W2519544049 cites W2163315971 @default.
- W2519544049 cites W2163729637 @default.
- W2519544049 cites W2165269787 @default.
- W2519544049 cites W2166320731 @default.
- W2519544049 cites W2318459593 @default.
- W2519544049 cites W2395078389 @default.
- W2519544049 cites W4230161101 @default.
- W2519544049 cites W4253820232 @default.
- W2519544049 doi "https://doi.org/10.1097/mpa.0000000000000647" @default.
- W2519544049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27623556" @default.
- W2519544049 hasPublicationYear "2016" @default.
- W2519544049 type Work @default.
- W2519544049 sameAs 2519544049 @default.
- W2519544049 citedByCount "9" @default.
- W2519544049 countsByYear W25195440492017 @default.
- W2519544049 countsByYear W25195440492018 @default.
- W2519544049 countsByYear W25195440492020 @default.
- W2519544049 countsByYear W25195440492021 @default.
- W2519544049 countsByYear W25195440492022 @default.
- W2519544049 countsByYear W25195440492023 @default.
- W2519544049 crossrefType "journal-article" @default.
- W2519544049 hasAuthorship W2519544049A5008903402 @default.
- W2519544049 hasAuthorship W2519544049A5049272282 @default.
- W2519544049 hasAuthorship W2519544049A5061652492 @default.
- W2519544049 hasAuthorship W2519544049A5067125554 @default.
- W2519544049 hasAuthorship W2519544049A5073565228 @default.
- W2519544049 hasAuthorship W2519544049A5076617999 @default.
- W2519544049 hasAuthorship W2519544049A5080981497 @default.
- W2519544049 hasAuthorship W2519544049A5083171620 @default.
- W2519544049 hasAuthorship W2519544049A5083391067 @default.
- W2519544049 hasConcept C126322002 @default.
- W2519544049 hasConcept C142724271 @default.
- W2519544049 hasConcept C153911025 @default.
- W2519544049 hasConcept C159654299 @default.