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- W2519555097 abstract "Clinical ineffectiveness of combined vaccination with 7-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in children with recurrent acute otitis media; a randomised double-blind study Objective. To determine the effectiveness of a combined vaccination with 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal polysaccharide vaccine in children with recurrent acute otitis media (AOM). Design. Prospective, double-blind, randomised study. Method A total of 383 patients aged I-6 years with two or more episodes of AOM in the year prior to study entry were included. Randomisation was stratified in 4 groups according to age (I2-24 months versus 25-83 months) and the number of previous AOM episodes per year (2-3 versus 4 or more). Children from the intervention group received either 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal polysaccharide vaccine and the control group was vaccinated with hepatitis-A or -B vaccines. All recurrences of AOM were established during an I8-month follow-up period. Secondary outcomes were nasopharyngeal pneumococcal carriage and pneumococci as pathogens of recurrent AOM episodes. Results. No reduction of AOM episodes was observed in the pneumococcal vaccine group compared to the control group (intention to treat analysis: relative risk: I.25; 95%-CI: 0.99-I.57). In the nasopharynx a shift from conjugate vaccine type pneumococci to non-vaccine types was observed. Conclusion. Combined 7-valent pneumococcal conjugate and 23-valent polysaccharide vaccination does not prevent AOM in children aged over I year who had already experienced recurrent episodes of AOM." @default.
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- W2519555097 date "2003-01-01" @default.
- W2519555097 modified "2023-09-23" @default.
- W2519555097 title "Klinische ineffectiviteit van gecombineerde vaccinatie met 7-valent pneumokokkenconjugaatvaccin en 23-valent pneumokokkenpolysacharidevaccin bij kinderen met recidiverende acute otitis media; een gerandomiseerd dubbelblind onderzoek" @default.
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