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- W2519603638 abstract "Lung cancer is the leading cause of cancer deaths worldwide. Since the number of patients responding well to current standard therapies is still small, further development of new anti-cancer drugs with minimum risk of adverse event is urgently awaited. To screen oncoantigens which could be used for the development of new diagnostic biomarkers and molecular targeted drugs, we have established a screening system as follows; i) To identify overexpressed genes in 120 lung cancers by genome-wide screening using the microarray representing 27,648 genes and pure populations of tumor cells taken from cancer tissues by laser microdissection, ii) To verify the candidate genes for their very low or absent expression in normal tissues by northern-blotting, iii) To validate the clinicopathological significance of their expression with tissue microarray covering hundreds of archived lung cancers, iv) To verify whether the target genes are essential for the growth or survival of cancer cells by RNAi and cell growth assays. During this process, we selected dozens of druggable oncoproteins with various enzymatic activities, and identified overexpression of Serine/Threonine phosphatase LAPP1 (lung cancer-associated protein phosphatase 1) in the majority of lung cancers and its scarce expression in normal tissues except testis. Strong LAPP1 expression was an independent prognostic factor for lung cancer patients who underwent curative surgery (P Citation Format: Yataro Daigo, Atsushi Takano, Yusuke Nakamura. Characterization of serine/threonine phosphatase LAPP1 as a diagnostic and therapeutic target for lung cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 690. doi:10.1158/1538-7445.AM2015-690" @default.
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- W2519603638 date "2015-08-01" @default.
- W2519603638 modified "2023-10-01" @default.
- W2519603638 title "Abstract 690: Characterization of serine/threonine phosphatase LAPP1 as a diagnostic and therapeutic target for lung cancer" @default.
- W2519603638 doi "https://doi.org/10.1158/1538-7445.am2015-690" @default.
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