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- W2519606469 abstract "Competitive quorum sensing (QS) antagonism offers a novel strategy for attenuating current multidrug resistant staphylococcal infections. To this end, a series of 10 truncated analogues based on the parent autoinducing peptides (AIPs) of Staphylococcus lugdunensis (groups I and II) and Staphylococcus epidermidis (groups I–III) were sequentially assessed against a newly developed Staphylococcus lugdunensis group I QS reporter strain. The truncated analogues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC50 values of 0.2 ± 0.01 μM and 0.3 ± 0.01 μM, while the truncated analogue of the Staphylococcus epidermidis AIP-1 (3) elicited an IC50 value of 2.7 ± 0.1 μM. These findings demonstrate the potential of cognate and “crosstalk” competitive quorum sensing inhibition using truncated AIPs as a means of attenuating staphylococcal infections in species beyond Staphylococcus aureus." @default.
- W2519606469 created "2016-09-23" @default.
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- W2519606469 date "2016-09-15" @default.
- W2519606469 modified "2023-10-02" @default.
- W2519606469 title "Truncated Autoinducing Peptides as Antagonists of <i>Staphylococcus lugdunensis</i> Quorum Sensing" @default.
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- W2519606469 doi "https://doi.org/10.1021/acs.jmedchem.6b00727" @default.
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