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- W2519648037 abstract "The protein product of the c-Cb1 proto-oncogene is involved in several signaling pathways and exerts a negative regulatory function on receptor and non-receptor tyrosine kinase. We used the overexpression experiment, and demonstrated that the c-Cb1 inhibits phosphorylation of intracellular protein in osteosarcoma cell line, SaOS2. Luciferase reporter assays revealed overexpression of c-Cb1 suppressed PDGF-induced c-Fos promoter activity as well as v-Src-induced STAT3 promoter activity. Thus, our results demonstrate that c-Cb1 negatively regulates several signaling pathways in the osteosarcoma cell line, suggesting that c-Cb1 is a good candidate for gene therapy against osteosarcoma." @default.
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- W2519648037 date "2002-01-01" @default.
- W2519648037 modified "2023-09-25" @default.
- W2519648037 title "Effect of Overexpression of c-Cb1 on Osteosarcoma Cell Line, SaOS2." @default.
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- W2519648037 doi "https://doi.org/10.5035/nishiseisai.51.779" @default.
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