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- W2519659710 abstract "Background and Purpose: Before, we found an unusual resistance of mouse myeloid leukemia (ML) cells to high dose (1.280 J/m 2 ) of UVC light. In the present work we investigated if resistant fraction of ML cells could die by apoptosis. Moreover, we investigated the possible role of oncoproteins (c-Myc, Bcl-2) and tumor suppressor protein (p53) in UVC-resistant phenotype. Materials and Methods: RFM/Rij Zgr mice, 3-4months old, were used. After injection with 10 6 of living leukemia cells, the disease came to terminal phase. Spleen cells of leukemic mice and healthy mice (control) were exposure to UVC (dose from 5-1.280 J/m 2 ), and 4 or 24 hours later is determined the number of viable and apoptotic cells. The presence of c-Myc, Bcl-2 and p53 proteins was detected by immunocytochemical method. Statistical analysis was performed using Model 1 ANOVA, followed by a Bonferroni test. Results: Some fraction of ML cells and spleen cells of healthy donors survived 1.280 J/m 2 . Mostly of leukemia cells did not enter in apoptotic way of death, what is different to healthy spleen cells. In that case we observed a live »monster« cells, without apoptotic feature. In terminal phase of leukemia, the percentage of positive cells to all examined proteins are a lower than in healthy donors. UVC had not significant influence on the percentage of positive cells. Conclusion: Some fraction of ML cells can survive used doses of UVC. Destroyed levels of investigated proteins contribute to transforming phenotype and resistance of ML to UVC and apoptosis." @default.
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- W2519659710 date "2002-01-01" @default.
- W2519659710 modified "2023-09-28" @default.
- W2519659710 title "Resistance of mouse myeloid leukemia cells to apoptosis: involving of c-Myc, Bcl-2 and p53" @default.
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