FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519665324> ?p ?o ?g. }

• W2519665324 endingPage "e0162397" @default.
• W2519665324 startingPage "e0162397" @default.
• W2519665324 abstract "Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate—the benzyl isothiocyanate (BITC)—modulates the intracellular localization of the transcription factor Forkhead box O 1 (FOXO1). FoxO transcription factors can antagonize insulin effects and trigger a variety of cellular processes involved in tumor suppression, longevity, development and metabolism. The current study evaluated the ability of BITC—extracted as intact glucosinolate from nasturtium and hydrolyzed with myrosinase—to modulate i) the insulin-signaling pathway, ii) the intracellular localization of FOXO1 and, iii) the expression of proteins involved in gluconeogenesis, antioxidant response and detoxification. Stably transfected human osteosarcoma cells (U-2 OS) with constitutive expression of FOXO1 protein labeled with GFP (green fluorescent protein) were used to evaluate the effect of BITC on FOXO1. Human hepatoma HepG2 cell cultures were selected to evaluate the effect on gluconeogenic, antioxidant and detoxification genes and protein expression. BITC reduced the phosphorylation of protein kinase B (AKT/PKB) and FOXO1; promoted FOXO1 translocation from cytoplasm into the nucleus antagonizing the insulin effect; was able to down-regulate the gene and protein expression of gluconeogenic enzymes; and induced the gene expression of antioxidant and detoxification enzymes. Knockdown analyses with specific siRNAs showed that the expression of gluconeogenic genes was dependent on nuclear factor (erythroid derived)-like2 (NRF2) and independent of FOXO1, AKT and NAD-dependent deacetylase sirtuin-1 (SIRT1). The current study provides evidence that BITC might have a role in type 2 diabetes T2D by reducing hepatic glucose production and increasing antioxidant resistance." @default.
• W2519665324 created "2016-09-23" @default.
• W2519665324 creator A5007112683 @default.
• W2519665324 creator A5032941961 @default.
• W2519665324 creator A5073351502 @default.
• W2519665324 creator A5073754698 @default.
• W2519665324 creator A5080878881 @default.
• W2519665324 creator A5089297502 @default.
• W2519665324 date "2016-09-13" @default.
• W2519665324 modified "2023-10-09" @default.
• W2519665324 title "Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells" @default.
• W2519665324 cites W1569851802 @default.
• W2519665324 cites W1697594889 @default.
• W2519665324 cites W1820314031 @default.
• W2519665324 cites W1965210967 @default.
• W2519665324 cites W1965818907 @default.
• W2519665324 cites W1969792358 @default.
• W2519665324 cites W1970277428 @default.
• W2519665324 cites W1971206408 @default.
• W2519665324 cites W1975105798 @default.
• W2519665324 cites W1978581123 @default.
• W2519665324 cites W1983296500 @default.
• W2519665324 cites W1983979097 @default.
• W2519665324 cites W1986896225 @default.
• W2519665324 cites W1987927672 @default.
• W2519665324 cites W1993674440 @default.
• W2519665324 cites W1993925256 @default.
• W2519665324 cites W1996200651 @default.
• W2519665324 cites W1998410775 @default.
• W2519665324 cites W1998664970 @default.
• W2519665324 cites W2000310038 @default.
• W2519665324 cites W2000440562 @default.
• W2519665324 cites W2001604240 @default.
• W2519665324 cites W2005391598 @default.
• W2519665324 cites W2009010832 @default.
• W2519665324 cites W2011979785 @default.
• W2519665324 cites W2012567446 @default.
• W2519665324 cites W2016032649 @default.
• W2519665324 cites W2016575029 @default.
• W2519665324 cites W2020211134 @default.
• W2519665324 cites W2023973783 @default.
• W2519665324 cites W2026885757 @default.
• W2519665324 cites W2028164406 @default.
• W2519665324 cites W2032189098 @default.
• W2519665324 cites W2037806158 @default.
• W2519665324 cites W2042322942 @default.
• W2519665324 cites W2044068920 @default.
• W2519665324 cites W2046664372 @default.
• W2519665324 cites W2052695206 @default.
• W2519665324 cites W2055148149 @default.
• W2519665324 cites W2058988470 @default.
• W2519665324 cites W2059201682 @default.
• W2519665324 cites W2059743234 @default.
• W2519665324 cites W2060046111 @default.
• W2519665324 cites W2061722209 @default.
• W2519665324 cites W2065552408 @default.
• W2519665324 cites W2072410104 @default.
• W2519665324 cites W2074760984 @default.
• W2519665324 cites W2077907997 @default.
• W2519665324 cites W2080457679 @default.
• W2519665324 cites W2080863734 @default.
• W2519665324 cites W2087168227 @default.
• W2519665324 cites W2089050551 @default.
• W2519665324 cites W2096691922 @default.
• W2519665324 cites W2099260524 @default.
• W2519665324 cites W2105731956 @default.
• W2519665324 cites W2110734309 @default.
• W2519665324 cites W2116119718 @default.
• W2519665324 cites W2121000910 @default.
• W2519665324 cites W2122497259 @default.
• W2519665324 cites W2126384706 @default.
• W2519665324 cites W2129104524 @default.
• W2519665324 cites W2134183006 @default.
• W2519665324 cites W2140653555 @default.
• W2519665324 cites W2141228362 @default.
• W2519665324 cites W2147482684 @default.
• W2519665324 cites W2149124673 @default.
• W2519665324 cites W2161551303 @default.
• W2519665324 cites W2220789792 @default.
• W2519665324 cites W4233598832 @default.
• W2519665324 doi "https://doi.org/10.1371/journal.pone.0162397" @default.
• W2519665324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5021297" @default.
• W2519665324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27622707" @default.
• W2519665324 hasPublicationYear "2016" @default.
• W2519665324 type Work @default.
• W2519665324 sameAs 2519665324 @default.
• W2519665324 citedByCount "28" @default.
• W2519665324 countsByYear W25196653242017 @default.
• W2519665324 countsByYear W25196653242018 @default.
• W2519665324 countsByYear W25196653242019 @default.
• W2519665324 countsByYear W25196653242020 @default.
• W2519665324 countsByYear W25196653242021 @default.
• W2519665324 countsByYear W25196653242022 @default.
• W2519665324 countsByYear W25196653242023 @default.
• W2519665324 crossrefType "journal-article" @default.
• W2519665324 hasAuthorship W2519665324A5007112683 @default.
• W2519665324 hasAuthorship W2519665324A5032941961 @default.
• W2519665324 hasAuthorship W2519665324A5073351502 @default.

• next