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• W2519754465 startingPage "421" @default.
• W2519754465 abstract "The first effort was made to document that elemental diet was satisfactory in maintaining normal growth in rats.A second effort was made to determine the maximum resectability of the intestine when rats were fed only by the elemental diet. These experiments were done in 80 ten-week-old female Wister rats.Results obtained are as follows(1) Eight rats fed only by the elemental diet through gastrostomy for 20 days gained more weight than pre-operative weight (P<0.02), and a positive nitrogen balance was obtained when rats were given with calories of 303 cal/kg/day and 8.25g/kg/day of amino acids. Also long term experiment of giving the elemental diet by mouth for 60 days resulted in increase of body weight (P<0.001), and there was no abnormality in hematological and pathological evaluations.(2) Body weight became heavier than that of before operation in the rats with 70% or 80% resection of the small intestine with P<0.001 and P<0.05, respectively.In the latter group, however, recovery from surgical assault were delayed, the pancreas and lung were often compromised and blood urea nitrogen as well as serum enzymes such as s-GOT and s-GPT were abnormally high.In 90% resection rats mortality was very high (85.7%). Therefore, it was concluded that the maximum resectality of the small intestine was 70% when rats were fed by elemental diet.(3)If the ileocecal valve was resected, pre-operative body weight was not resumed even in 70%-resection rats, indicating the importance of the valve.(4) When pyloroplasty was added in 70%-resection rats, gain in body weight was larger as compared with 70% resection group and non-resection group (P<0.005 and P<0.01, respectively).Abnormal findings in the liver, pancreas and lung were lesser and serum protein was elevated (P<0.001).These results show that elemental diet is effective tool of nutrition and exclusion of small intestine can be done safely as much as 70%However, improvement of administration and nutritional constitution may be able to endure much more extensive resection." @default.
• W2519754465 created "2016-09-23" @default.
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• W2519754465 date "1978-01-01" @default.
• W2519754465 modified "2023-09-25" @default.
• W2519754465 title "Study of the elemental diet" @default.
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• W2519754465 doi "https://doi.org/10.4044/joma1947.90.3-4_421" @default.
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