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• W2519761140 endingPage "123014" @default.
• W2519761140 startingPage "123014" @default.
• W2519761140 abstract "Fibroblast–myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from highly injured regions, like infarcted or ischemic zones, to less-wounded regions of the tissue. Fibrotic hearts are known to be prone to arrhythmias, so it is important to understand the effects of GFD in the formation and sustenance of arrhythmic re-entrant waves, like spiral or scroll waves. Therefore, we investigate the effects of GFD on the stability of spiral and scroll waves of electrical activation in a state-of-the-art mathematical model for cardiac tissue in which we also include fibroblasts. By introducing GFD in controlled ways, we show that spiral and scroll waves can be unstable in the presence of GFDs because of regions with varying spiral- or scroll-wave frequency ω, induced by the GFD. We examine the effects of the resting membrane potential of the fibroblast and the number of fibroblasts attached to the myocytes on the stability of these waves. Finally, we show that the presence of GFDs can lead to the formation of spiral waves at high-frequency pacing." @default.
• W2519761140 created "2016-09-23" @default.
• W2519761140 creator A5020809479 @default.
• W2519761140 creator A5023546707 @default.
• W2519761140 date "2016-12-12" @default.
• W2519761140 modified "2023-10-14" @default.
• W2519761140 title "Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast–myocyte coupling" @default.
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• W2519761140 doi "https://doi.org/10.1088/1367-2630/18/12/123014" @default.
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