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• W2519810701 abstract "Significance Advances in molecular-targeted optical imaging probes offer the opportunity to identify and monitor pathophysiologic processes; to achieve this promise, there is an important need to develop devices capable of imaging probes in vivo at the cellular level. The challenge is to build devices that overcome the many optical and mechanical challenges associated with imaging soft tissue inside the body. Fiber optic microendoscopy has shown promise for in vivo imaging, but image contrast in highly scattering tissue is severely limited by out-of-focus light. In this paper, we demonstrate differential structured illumination microendoscopy (DSIMe) to image molecular contrast agents in vivo. We demonstrate improved image contrast of DSIMe when imaging patients with cervical adenocarcinoma in situ to detect atypia associated with neoplasia." @default.
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• W2519810701 date "2016-09-12" @default.
• W2519810701 modified "2023-10-12" @default.
• W2519810701 title "Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents" @default.
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• W2519810701 doi "https://doi.org/10.1073/pnas.1613497113" @default.
• W2519810701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5047189" @default.
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