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- W2519854927 abstract "Pleural effusions have classically been divided into transudates and exudates. If it is exudative, more diagnostic tests are required in order to determine the cause of the local disease. Malignancy is a common and important cause of exudative pleural effusions. Because pleural fluid cytology and pleural biopsy specimens do not provide a diagnosis in a high percentage of malignant effusions, several tumor markers have been studied. To overcome this limitation, we hypothesized that measurement of melanoma antigen gene (MAGE) would be useful in differentiating between benign and malignant effusion. We studied prospectively 127 consecutive patients with pleural effusion (malignant 42, tuberculous 27, parapneumonic 17, empyema 5, transudative 21, miscellaneous 3, nondiagnostic 12). We examined standard parameters of pleural effusion and measured the expression of MAGE and cytology with the obtained pleural effusion. Expression of MAGE was interpreted by means of a commercial kit using RT-PCR method. The sensitivity and specificity of cytology were 45.2% and 100% respectively and the positive predictive value and negative predictive value of cytology were also 100% and 76.0% respectively. The sensitivity and specificity of MAGE were 27.0% and 98.5% respectively and the positive predictive value and negative predictive value of MAGE were also 90.9% and 71.3% respectively. Using the cutoff value of 3 μg/L for CEA, the combination of MAGE and CEA in pleural fluid revealed 71.4% sensitivity and 89.0% specificity in diagnosis of malignant pleural effusion. The findings of this study suggest that the combination of MAGE and CEA in addition with pleural fluid cytology would be useful as a diagnostic marker in differentiating between benign and malignant pleural effusion." @default.
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- W2519854927 date "2007-08-01" @default.
- W2519854927 modified "2023-10-16" @default.
- W2519854927 title "P1-135: Diagnostic value of melanoma antigen gene in differentiation of pleural effusions" @default.
- W2519854927 doi "https://doi.org/10.1097/01.jto.0000283749.62727.d4" @default.
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