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• W2519898467 abstract "Biofilms are difficult to eradicate due to a protective architecture and create major challenges in patient care by diminishing both host immune response and therapeutic approaches. This study investigated a new strategy for treating surface-attached biofilms by delivering germicidal UV through a material surface in a process referred to as inside-out sterilization (IOS). Mature Pseudomonas aeruginosa (ATCC® 27853™ ) biofilms were irradiated with up to 1400 mJ cm-2 of germicidal UV from both ambient and IOS configurations. The lethal dose for the ambient exposure group was 461 mJ cm-2 95% CI [292, 728] compared to the IOS treatment group of 247 mJ cm-2 95% CI [187, 325], corresponding to 47% less UV dosage for the IOS group (P < 0.05). This study demonstrated that with IOS, a lower quantal dosage of UV energy is required to eradicate biofilm than with ambient exposure by leveraging the organizational structure of the biofilm." @default.
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• W2519898467 date "2016-10-18" @default.
• W2519898467 modified "2023-09-24" @default.
• W2519898467 title "Inside-out Ultraviolet-C Sterilization ofPseudomonas aeruginosaBiofilmIn Vitro" @default.
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• W2519898467 doi "https://doi.org/10.1111/php.12637" @default.
• W2519898467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5161631" @default.
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• W2519898467 hasPublicationYear "2016" @default.
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