FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2519985598> ?p ?o ?g. }

• W2519985598 endingPage "62" @default.
• W2519985598 startingPage "56" @default.
• W2519985598 abstract "To elucidate whether trophoblast expansion and invasion are modulated by androgen signaling in an in vitro co-culture model system with decidualizing endometrial stromal cells (ESCs).We employed an in vitro co-culture model of early embryo implantation, consisting of human ESCs (EtsT499 cells) and spheroids generated by extravillous trophoblast (EVT) derived HTR8/Svneo. The ESCs were decidualized with 8-bromo-cAMP (8-br-cAMP) in the presence or absence of dihydrotestosterone (DHT) at various concentrations for 5 days before co-culture with EVT spheroids. Trophoblast expansion was monitored by fluorescent time-lapse imaging microscopy. ESCs motility was visualized by using CellTracker™ Orange CMRA fluorescent probe. Apoptosis of ESCs was detected by CellEvent™ Caspase-3/7® green detection reagent. Invasion assays were performed to quantify EVT invasion through a chemotaxis cell membrane.Expansion of EVT spheroids was significantly enhanced by decidualized compared to undifferentiated ESCs. This process was further stimulated if ESCs were first decidualized in the presence of DHT. In contrast to decidualized ESCs, undifferentiated cells actively migrated away from expanding EVT spheroids. Invasiveness of EVT toward decidualized ESCs was significantly attenuated in comparison to undifferentiated ESCs. DHT had no effect on EVT invasion. However, an inhibitor of intercellular gap junction communication significantly enhanced EVT invasion towards decidualized ESCs.These results indicate distinct roles for androgen signaling and gap junction formation in decidual cells in regulating trophoblast expansion and invasion." @default.
• W2519985598 created "2016-09-23" @default.
• W2519985598 creator A5022463365 @default.
• W2519985598 creator A5025845183 @default.
• W2519985598 creator A5025948761 @default.
• W2519985598 creator A5031720346 @default.
• W2519985598 creator A5038406781 @default.
• W2519985598 creator A5041768552 @default.
• W2519985598 creator A5046088729 @default.
• W2519985598 creator A5055755902 @default.
• W2519985598 date "2016-11-01" @default.
• W2519985598 modified "2023-09-27" @default.
• W2519985598 title "Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture: A time-lapse study" @default.
• W2519985598 cites W108658453 @default.
• W2519985598 cites W1548915688 @default.
• W2519985598 cites W1602321628 @default.
• W2519985598 cites W1893005658 @default.
• W2519985598 cites W1970351535 @default.
• W2519985598 cites W1971128078 @default.
• W2519985598 cites W1973749422 @default.
• W2519985598 cites W1976795828 @default.
• W2519985598 cites W1986244792 @default.
• W2519985598 cites W1989045095 @default.
• W2519985598 cites W1989978684 @default.
• W2519985598 cites W1991401695 @default.
• W2519985598 cites W1991534579 @default.
• W2519985598 cites W2002806671 @default.
• W2519985598 cites W2004097699 @default.
• W2519985598 cites W2031073159 @default.
• W2519985598 cites W2034492080 @default.
• W2519985598 cites W2040613067 @default.
• W2519985598 cites W2049014099 @default.
• W2519985598 cites W2055035644 @default.
• W2519985598 cites W2057427640 @default.
• W2519985598 cites W2065108383 @default.
• W2519985598 cites W2065595849 @default.
• W2519985598 cites W2067106228 @default.
• W2519985598 cites W2078156035 @default.
• W2519985598 cites W2079350838 @default.
• W2519985598 cites W2092182760 @default.
• W2519985598 cites W2111369394 @default.
• W2519985598 cites W2112675387 @default.
• W2519985598 cites W2113400357 @default.
• W2519985598 cites W2119975890 @default.
• W2519985598 cites W2121542458 @default.
• W2519985598 cites W2126195456 @default.
• W2519985598 cites W2132049525 @default.
• W2519985598 cites W2133303552 @default.
• W2519985598 cites W2134046709 @default.
• W2519985598 cites W2147007332 @default.
• W2519985598 cites W2151780324 @default.
• W2519985598 cites W2257112383 @default.
• W2519985598 cites W2318921435 @default.
• W2519985598 cites W2326377974 @default.
• W2519985598 cites W2340082279 @default.
• W2519985598 cites W1769177823 @default.
• W2519985598 doi "https://doi.org/10.1016/j.placenta.2016.09.005" @default.
• W2519985598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27780540" @default.
• W2519985598 hasPublicationYear "2016" @default.
• W2519985598 type Work @default.
• W2519985598 sameAs 2519985598 @default.
• W2519985598 citedByCount "18" @default.
• W2519985598 countsByYear W25199855982017 @default.
• W2519985598 countsByYear W25199855982019 @default.
• W2519985598 countsByYear W25199855982020 @default.
• W2519985598 countsByYear W25199855982021 @default.
• W2519985598 countsByYear W25199855982022 @default.
• W2519985598 countsByYear W25199855982023 @default.
• W2519985598 crossrefType "journal-article" @default.
• W2519985598 hasAuthorship W2519985598A5022463365 @default.
• W2519985598 hasAuthorship W2519985598A5025845183 @default.
• W2519985598 hasAuthorship W2519985598A5025948761 @default.
• W2519985598 hasAuthorship W2519985598A5031720346 @default.
• W2519985598 hasAuthorship W2519985598A5038406781 @default.
• W2519985598 hasAuthorship W2519985598A5041768552 @default.
• W2519985598 hasAuthorship W2519985598A5046088729 @default.
• W2519985598 hasAuthorship W2519985598A5055755902 @default.
• W2519985598 hasConcept C126322002 @default.
• W2519985598 hasConcept C134018914 @default.
• W2519985598 hasConcept C16930146 @default.
• W2519985598 hasConcept C172680121 @default.
• W2519985598 hasConcept C196843134 @default.
• W2519985598 hasConcept C2776953305 @default.
• W2519985598 hasConcept C2777495146 @default.
• W2519985598 hasConcept C2777911890 @default.
• W2519985598 hasConcept C2778316770 @default.
• W2519985598 hasConcept C2779234561 @default.
• W2519985598 hasConcept C2780197806 @default.
• W2519985598 hasConcept C502942594 @default.
• W2519985598 hasConcept C54355233 @default.
• W2519985598 hasConcept C71315377 @default.
• W2519985598 hasConcept C71924100 @default.
• W2519985598 hasConcept C86803240 @default.
• W2519985598 hasConcept C95444343 @default.
• W2519985598 hasConceptScore W2519985598C126322002 @default.
• W2519985598 hasConceptScore W2519985598C134018914 @default.
• W2519985598 hasConceptScore W2519985598C16930146 @default.
• W2519985598 hasConceptScore W2519985598C172680121 @default.

• next