FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520004034> ?p ?o ?g. }

• W2520004034 abstract "Clinical manifestations in leprosy, a chronic infectious disease caused by Mycobacterium leprae, depend on the immunologic reactions of the patient to the bacilli. Previously, we have shown a reversion of the inefficiency of the cellular-mediated immune response against M. leprae in lepromatous leprosy patients when dendritic cells (DCs) were used in vitro as APC. The aim of the current study is to investigate the cell-to-cell interaction when purified human monocytes-derived DCs and macrophages from healthy adult donors were co-cultured with autologous lymphocytes in the presence of either M. leprae or M. bovis BCG by using APCs which were either attached or in suspension. Subsequently, APCs were analyzed by optical microscopy, phenotypically monitored by flow cytometry, and cytokines secretion evaluated by ELISA and Luminex. Overall, our results suggest that: (1) the process of adhesion of the APC may not be absolutely essential for antigen presentation activity; (2) IL-12 production appears to be in direct relation to the susceptibility of the host cell to infection with M. leprae; (3) in the presence of autologous lymphocytes, there is a down-modulation of surface markers studied, except for CD209 in M. leprae-infected CD11c+ DCs, although a similar decreased expression of these markers on macrophages was also observed, and this step occurs in an antigen-dependent manner; and (4) the cytokines secretion is also dependent on the APCs’ adhesion process. In parallel, the human THP-1 cell line was assessed showing that no monokine was differentially regulated when cells remained either attached or in suspension, regardless of the stimulus employed. These results may further guide future pivotal experimental procedures when studying in vitro cellular immune responses against mycobacteria." @default.
• W2520004034 created "2016-09-23" @default.
• W2520004034 creator A5006607649 @default.
• W2520004034 creator A5013259094 @default.
• W2520004034 creator A5023922727 @default.
• W2520004034 creator A5029712667 @default.
• W2520004034 creator A5059569122 @default.
• W2520004034 creator A5066037763 @default.
• W2520004034 date "2016-01-01" @default.
• W2520004034 modified "2023-10-07" @default.
• W2520004034 title "The Differential In Vitro Presentation of Mycobacterium leprae Antigens by Human Dendritic Cells is determined by the Mechanism of Host Cell Adhesion" @default.
• W2520004034 cites W1480778114 @default.
• W2520004034 cites W1573750075 @default.
• W2520004034 cites W1602206861 @default.
• W2520004034 cites W1957213149 @default.
• W2520004034 cites W1966837270 @default.
• W2520004034 cites W1974440224 @default.
• W2520004034 cites W1977078089 @default.
• W2520004034 cites W1999066791 @default.
• W2520004034 cites W2003635168 @default.
• W2520004034 cites W2015954946 @default.
• W2520004034 cites W2020871710 @default.
• W2520004034 cites W2021736378 @default.
• W2520004034 cites W2036307552 @default.
• W2520004034 cites W2040995271 @default.
• W2520004034 cites W2044453948 @default.
• W2520004034 cites W2050021402 @default.
• W2520004034 cites W2062254683 @default.
• W2520004034 cites W2073408529 @default.
• W2520004034 cites W2079432720 @default.
• W2520004034 cites W2080439683 @default.
• W2520004034 cites W2081771870 @default.
• W2520004034 cites W2083872083 @default.
• W2520004034 cites W2085869008 @default.
• W2520004034 cites W2088024377 @default.
• W2520004034 cites W2092699319 @default.
• W2520004034 cites W2101423698 @default.
• W2520004034 cites W2104941073 @default.
• W2520004034 cites W2108961981 @default.
• W2520004034 cites W2111668089 @default.
• W2520004034 cites W2111695773 @default.
• W2520004034 cites W2112546054 @default.
• W2520004034 cites W2124626543 @default.
• W2520004034 cites W2127310510 @default.
• W2520004034 cites W2127954824 @default.
• W2520004034 cites W2129174799 @default.
• W2520004034 cites W2133281306 @default.
• W2520004034 cites W2135597173 @default.
• W2520004034 cites W2138386305 @default.
• W2520004034 cites W2145049340 @default.
• W2520004034 cites W2157305533 @default.
• W2520004034 cites W2167238343 @default.
• W2520004034 cites W2169420357 @default.
• W2520004034 cites W2233128253 @default.
• W2520004034 cites W2312242233 @default.
• W2520004034 cites W2990064884 @default.
• W2520004034 cites W880969314 @default.
• W2520004034 doi "https://doi.org/10.4172/2155-9899.1000443" @default.
• W2520004034 hasPublicationYear "2016" @default.
• W2520004034 type Work @default.
• W2520004034 sameAs 2520004034 @default.
• W2520004034 citedByCount "0" @default.
• W2520004034 crossrefType "journal-article" @default.
• W2520004034 hasAuthorship W2520004034A5006607649 @default.
• W2520004034 hasAuthorship W2520004034A5013259094 @default.
• W2520004034 hasAuthorship W2520004034A5023922727 @default.
• W2520004034 hasAuthorship W2520004034A5029712667 @default.
• W2520004034 hasAuthorship W2520004034A5059569122 @default.
• W2520004034 hasAuthorship W2520004034A5066037763 @default.
• W2520004034 hasBestOaLocation W25200040341 @default.
• W2520004034 hasConcept C147483822 @default.
• W2520004034 hasConcept C203014093 @default.
• W2520004034 hasConcept C2776090121 @default.
• W2520004034 hasConcept C2778170410 @default.
• W2520004034 hasConcept C2779823659 @default.
• W2520004034 hasConcept C2779846462 @default.
• W2520004034 hasConcept C2780695269 @default.
• W2520004034 hasConcept C49039625 @default.
• W2520004034 hasConcept C553184892 @default.
• W2520004034 hasConcept C55493867 @default.
• W2520004034 hasConcept C67662055 @default.
• W2520004034 hasConcept C83464605 @default.
• W2520004034 hasConcept C86803240 @default.
• W2520004034 hasConcept C8891405 @default.
• W2520004034 hasConcept C89423630 @default.
• W2520004034 hasConceptScore W2520004034C147483822 @default.
• W2520004034 hasConceptScore W2520004034C203014093 @default.
• W2520004034 hasConceptScore W2520004034C2776090121 @default.
• W2520004034 hasConceptScore W2520004034C2778170410 @default.
• W2520004034 hasConceptScore W2520004034C2779823659 @default.
• W2520004034 hasConceptScore W2520004034C2779846462 @default.
• W2520004034 hasConceptScore W2520004034C2780695269 @default.
• W2520004034 hasConceptScore W2520004034C49039625 @default.
• W2520004034 hasConceptScore W2520004034C553184892 @default.
• W2520004034 hasConceptScore W2520004034C55493867 @default.
• W2520004034 hasConceptScore W2520004034C67662055 @default.
• W2520004034 hasConceptScore W2520004034C83464605 @default.
• W2520004034 hasConceptScore W2520004034C86803240 @default.
• W2520004034 hasConceptScore W2520004034C8891405 @default.
• W2520004034 hasConceptScore W2520004034C89423630 @default.

• next