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- W2520036449 endingPage "336" @default.
- W2520036449 startingPage "324" @default.
- W2520036449 abstract "Emerging evidence revealed that abrogated cell cycle entry into highly differentiated mature neurons and muscles is having detrimental consequences in response to cell cycle checkpoints disruption, altered signaling cascades, pathophysiological and external stimuli, for instance, Aβ, Parkin, p-tau, α-synuclein, impairment in TRK, Akt/GSK3β, MAPK/Hsp90, and oxidative stress. These factors, reinitiate undesired cell division by triggering new DNA synthesis, replication, and thus exquisitely forced mature cell to enter into a disturbed and vulnerable state that often leads to death as reported in many neuro- and myodegenerative disorders. A pertinent question arises how to reverse this unwanted pathophysiological phenomenon is attributed to the usage of cell cycle inhibitors to prevent the degradation of crucial cell cycle arresting proteins, cyclin inhibitors, chaperones and E3 ligases. Herein, we identified the major culprits behind the forceful cell cycle re-entry, elucidated the cyclin re-expression based on disturbed signaling mechanisms in neuromuscular degeneration together with plausible therapeutic strategies." @default.
- W2520036449 created "2016-09-23" @default.
- W2520036449 creator A5006548312 @default.
- W2520036449 creator A5027341366 @default.
- W2520036449 creator A5051075144 @default.
- W2520036449 creator A5054173631 @default.
- W2520036449 creator A5062138228 @default.
- W2520036449 creator A5072893975 @default.
- W2520036449 date "2017-01-01" @default.
- W2520036449 modified "2023-09-29" @default.
- W2520036449 title "Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?" @default.
- W2520036449 cites W1120256502 @default.
- W2520036449 cites W1480475289 @default.
- W2520036449 cites W1485747833 @default.
- W2520036449 cites W1488504944 @default.
- W2520036449 cites W1496714204 @default.
- W2520036449 cites W1532965294 @default.
- W2520036449 cites W1533318596 @default.
- W2520036449 cites W1551254293 @default.
- W2520036449 cites W1551854884 @default.
- W2520036449 cites W1708325824 @default.
- W2520036449 cites W1907721275 @default.
- W2520036449 cites W1923683854 @default.
- W2520036449 cites W1965071293 @default.
- W2520036449 cites W1965392554 @default.
- W2520036449 cites W1966142302 @default.
- W2520036449 cites W1969417329 @default.
- W2520036449 cites W1973083723 @default.
- W2520036449 cites W1981725854 @default.
- W2520036449 cites W1984580850 @default.
- W2520036449 cites W1985139403 @default.
- W2520036449 cites W1987456989 @default.
- W2520036449 cites W1989124659 @default.
- W2520036449 cites W1989227773 @default.
- W2520036449 cites W1989280457 @default.
- W2520036449 cites W1989742315 @default.
- W2520036449 cites W1991194956 @default.
- W2520036449 cites W1991199800 @default.
- W2520036449 cites W1992830187 @default.
- W2520036449 cites W1999607830 @default.
- W2520036449 cites W2001225526 @default.
- W2520036449 cites W2003834447 @default.
- W2520036449 cites W2004508412 @default.
- W2520036449 cites W2005202312 @default.
- W2520036449 cites W2005221785 @default.
- W2520036449 cites W2008661368 @default.
- W2520036449 cites W2011677622 @default.
- W2520036449 cites W2013992987 @default.
- W2520036449 cites W2017688136 @default.
- W2520036449 cites W2019420937 @default.
- W2520036449 cites W2022285621 @default.
- W2520036449 cites W2022410893 @default.
- W2520036449 cites W2026443859 @default.
- W2520036449 cites W2026826560 @default.
- W2520036449 cites W2029866453 @default.
- W2520036449 cites W2031471262 @default.
- W2520036449 cites W2032195804 @default.
- W2520036449 cites W2033349885 @default.
- W2520036449 cites W2033599203 @default.
- W2520036449 cites W2034187906 @default.
- W2520036449 cites W2035711542 @default.
- W2520036449 cites W2036552456 @default.
- W2520036449 cites W2038314898 @default.
- W2520036449 cites W2039171882 @default.
- W2520036449 cites W2044381566 @default.
- W2520036449 cites W2045139609 @default.
- W2520036449 cites W2047803672 @default.
- W2520036449 cites W2049628649 @default.
- W2520036449 cites W2055874717 @default.
- W2520036449 cites W2058364486 @default.
- W2520036449 cites W2058641375 @default.
- W2520036449 cites W2063265423 @default.
- W2520036449 cites W2068938464 @default.
- W2520036449 cites W2073765028 @default.
- W2520036449 cites W2074521925 @default.
- W2520036449 cites W2075757461 @default.
- W2520036449 cites W2076790297 @default.
- W2520036449 cites W2077794733 @default.
- W2520036449 cites W2078163062 @default.
- W2520036449 cites W2078654893 @default.
- W2520036449 cites W2079976343 @default.
- W2520036449 cites W2088686374 @default.
- W2520036449 cites W2088924033 @default.
- W2520036449 cites W2092647016 @default.
- W2520036449 cites W2095410725 @default.
- W2520036449 cites W2100905208 @default.
- W2520036449 cites W2101579411 @default.
- W2520036449 cites W2102904613 @default.
- W2520036449 cites W2103957625 @default.
- W2520036449 cites W2104128198 @default.
- W2520036449 cites W2109572744 @default.
- W2520036449 cites W2119838074 @default.
- W2520036449 cites W2121774696 @default.
- W2520036449 cites W2125443397 @default.
- W2520036449 cites W2126895514 @default.
- W2520036449 cites W2130106568 @default.
- W2520036449 cites W2130356495 @default.
- W2520036449 cites W2134829658 @default.