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• W2520051922 startingPage "32" @default.
• W2520051922 abstract "This study explored anhedonia (lack of interest or pleasure in non-drug rewards) as a potentially modifiable individual difference associated with the effectiveness of Contingency Management (CM). It also tested the hypothesis that a dopaminergic drug, levodopa (L-DOPA), would improve the effectiveness of CM, particularly in individuals high in anhedonia. The study was a single-site, randomized, double-blind, parallel group, 12-week trial comparing L-DOPA with placebo, with both medication groups receiving voucher-based CM targeting cocaine-negative urines. Participants were N=85 treatment-seeking adults with CUD. Anhedonia was measured at baseline using a validated self-report measure and a progressive ratio behavioral measure. Treatment Effectiveness Score (TES) was defined as the total number of cocaine-negative urines submitted. Analyses based on Frequentist general linear models were not significant, but Bayesian analyses indicated a high probability (92.6%) that self-reported anhedonia was associated with poor treatment outcomes (lower TES). L-DOPA did not significantly improve outcomes, nor was the effect of L-DOPA moderated by anhedonia. While the study failed to replicate positive findings from previous studies of L-DOPA in combination with CM, it does provide preliminary evidence that anhedonia may be a modifiable individual difference associated with poorer CM outcomes." @default.
• W2520051922 created "2016-09-23" @default.
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• W2520051922 date "2017-01-01" @default.
• W2520051922 modified "2023-09-23" @default.
• W2520051922 title "Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder" @default.
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• W2520051922 doi "https://doi.org/10.1016/j.jsat.2016.08.020" @default.
• W2520051922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5154907" @default.
• W2520051922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27646197" @default.
• W2520051922 hasPublicationYear "2017" @default.
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