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- W2520079957 abstract "1,2,3,4-Tetrahydroisoquinoline (THIQ) is one of the 'privileged scaffolds', commonly found in nature. Initially, this class of compounds was known for its neurotoxicity. Later on, 1-methyl-1,2,3,4-tetrahydroisoquinoline was proved as an endogeneous Parkinsonism-preventing agent in mammals. The fused THIQs have been studied for their role as anticancer antibiotics. The US FDA approval of the trabectedin for the treatment of soft tissue sarcomas, is a milestone in the anticancer drug discovery. Areas covered: This review covers the patents on various therapeutic activities of the THIQ derivatives in the years between 2010 and 2015. Patents were collected using a thorough search of Espacenet and WIPO databases. The therapeutic areas covered include cancer, malaria, central nervous system (CNS), cardiovascular, metabolic disorders, and so on. This also includes several patents on specific THIQs of clinical importance. Expert opinion: A large number of the THIQ derivatives have been synthesised for various therapeutic activities, with noticeable success in the area of drug discovery for cancer and CNS. They may also prove to be promising candidates for various infectious diseases, such as malaria, tuberculosis, HIV-infection, HSV-infection, leishmaniasis, etc. They can also be developed as novel class of drugs for various therapeutic activities with unique mechanism of action." @default.
- W2520079957 created "2016-09-23" @default.
- W2520079957 creator A5003890674 @default.
- W2520079957 creator A5044365180 @default.
- W2520079957 date "2016-09-22" @default.
- W2520079957 modified "2023-10-16" @default.
- W2520079957 title "Tetrahydroisoquinolines in therapeutics: a patent review (2010-2015)" @default.
- W2520079957 cites W1561978674 @default.
- W2520079957 cites W1596260790 @default.
- W2520079957 cites W1604468403 @default.
- W2520079957 cites W1977558570 @default.
- W2520079957 cites W1978579630 @default.
- W2520079957 cites W1981272517 @default.
- W2520079957 cites W1981303092 @default.
- W2520079957 cites W1984221372 @default.
- W2520079957 cites W1989212094 @default.
- W2520079957 cites W1993491755 @default.
- W2520079957 cites W1995114136 @default.
- W2520079957 cites W1999896636 @default.
- W2520079957 cites W2003692520 @default.
- W2520079957 cites W2004839884 @default.
- W2520079957 cites W2007267134 @default.
- W2520079957 cites W2007566466 @default.
- W2520079957 cites W2008757142 @default.
- W2520079957 cites W2009664257 @default.
- W2520079957 cites W2015629450 @default.
- W2520079957 cites W2018207295 @default.
- W2520079957 cites W2018597141 @default.
- W2520079957 cites W2020650719 @default.
- W2520079957 cites W2021202623 @default.
- W2520079957 cites W2027740042 @default.
- W2520079957 cites W2032972507 @default.
- W2520079957 cites W2037388005 @default.
- W2520079957 cites W2049771698 @default.
- W2520079957 cites W2053528730 @default.
- W2520079957 cites W2057320402 @default.
- W2520079957 cites W2061773314 @default.
- W2520079957 cites W2064967022 @default.
- W2520079957 cites W2068117029 @default.
- W2520079957 cites W2069511586 @default.
- W2520079957 cites W2084910781 @default.
- W2520079957 cites W2085879736 @default.
- W2520079957 cites W2089686100 @default.
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- W2520079957 cites W2099814988 @default.
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- W2520079957 cites W2106350754 @default.
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- W2520079957 cites W2134807618 @default.
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- W2520079957 doi "https://doi.org/10.1080/13543776.2017.1236084" @default.
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