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• W2520145144 abstract "19 Chronic cigarette smoke (CS) exposure provokes variable changes in the lungs, and 20 emphysema is an important feature of chronic obstructive pulmonary disease. The 21 usefulness of micro computed tomography (CT) to assess emphysema in different 22 mouse models has been investigated, but few studies evaluated the dynamic structural 23 changes in a CS-induced emphysema mouse model. A novel micro CT technique with 24 respiratory and cardiac gating has resulted in high-quality images that enable processing 25 for further quantitative and qualitative analyses. 26 Adult female C57BL/6J mice were repeatedly exposed to mainstream CS, and micro 27 CT scans were performed at 0, 4, 12, and 20 weeks. Emphysema was also histologically 28 quantified at each time point. Air-exposed mice and mice treated with intratracheal 29 elastase served as controls and comparisons, respectively. 30 End-expiratory lung volume, corresponding to functional residual volume, was defined 31 as the calculated volume at the phase of end-expiration, and it evaluated air trapping. 32 The end-expiratory lung volumes of CS-exposed mice were significantly larger than 33 those of air controls at 12 and 20 weeks, which was in line with alveolar enlargement 34 and destruction by histological quantification. However, CS exposure neither increased 35 low attenuation volume nor decreased the average lung CT value at any time point, 36 unlike the elastase-instilled emphysema model. CS-exposed mice had rather higher 37 average lung CT values at 4 and 12 weeks. 38 This is the first study characterizing a CS-induced emphysema model on micro CT 39 over time in mice. Moreover, these findings extend our understanding of the distinct 40 pathophysiology of CS-induced emphysema in mice. 41" @default.
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• W2520145144 date "2015-01-01" @default.
• W2520145144 modified "2023-09-27" @default.
• W2520145144 title "Evaluation of cigarette smoke-induced emphysema in mice using" @default.
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• W2520145144 hasPublicationYear "2015" @default.
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