Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520173345> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2520173345 abstract "Heart failure with preserved ejection fraction (HFpEF) accounts for at least half of the heart failure (HF) hospitalizations in North America.1 The symptoms of HFpEF generally center around 2 main features: (1) dyspnea, likely reflective of pulmonary congestion, and (2) exertional intolerance, consistent with inefficient oxygen delivery or utilization. After an HF hospitalization, survival is poor.2 Despite the scope and seriousness of this problem, no targeted therapeutic intervention has been clearly identified to decrease the morbidity or mortality from this syndrome. Treatment has, therefore, largely focused on the management of comorbidities and volume status. The reasons for failing to identify effective therapeutic interventions in HFpEF are varied but primarily revolve around the clinical heterogeneity of the condition with significant difficulties in providing a unifying pathophysiology for this syndrome and consequent challenges in clinical trial design.Article, see p 880 Yet, patients with HFpEF have distinct identifiable abnormalities in vascular and endothelial function, which may help tie together the varied systemic and cardiac manifestations of this condition with its associated comorbidities. Endothelial dysfunction is indicative of impaired endothelium-mediated nitric oxide (NO) bioavailability and can be assessed clinically by demonstrating a deficient vasodilatory response to various stimuli. NO, through stimulation of guanylate cyclase, leads to the generation of the second-messenger molecule cyclic guanosine monophosphate, which depending on the cell type, results in multiple fundamental downstream processes, such as contraction, relaxation, cell growth, apoptosis, and specific gene expression.3 Paulus and Tschope4 described coronary microvascular endothelial inflammation in HFpEF resulting in decreased NO bioavailability, low cyclic guanosine monophosphate content, and reduced protein kinase G activity in cardiomyocytes. This decreased protein kinase G activity favors the development of cardiac hypertrophy and, because of hypophosphorylation of titin, increases resting tension in cardiomyocytes. In fact, it has been proposed that correction of myocardial …" @default.
- W2520173345 created "2016-09-23" @default.
- W2520173345 creator A5026740203 @default.
- W2520173345 creator A5082176880 @default.
- W2520173345 date "2016-09-16" @default.
- W2520173345 modified "2023-09-28" @default.
- W2520173345 title "Taking NO for an Answer" @default.
- W2520173345 cites W164205712 @default.
- W2520173345 cites W1791835599 @default.
- W2520173345 cites W2000501615 @default.
- W2520173345 cites W2069060200 @default.
- W2520173345 cites W2090111676 @default.
- W2520173345 cites W2101791328 @default.
- W2520173345 cites W2112155198 @default.
- W2520173345 cites W2137784332 @default.
- W2520173345 cites W2139605571 @default.
- W2520173345 cites W2152791175 @default.
- W2520173345 cites W2166504467 @default.
- W2520173345 cites W2179146111 @default.
- W2520173345 cites W2213926659 @default.
- W2520173345 cites W2275686028 @default.
- W2520173345 cites W2462116812 @default.
- W2520173345 cites W2476146068 @default.
- W2520173345 cites W2082890993 @default.
- W2520173345 doi "https://doi.org/10.1161/circresaha.116.309623" @default.
- W2520173345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27635080" @default.
- W2520173345 hasPublicationYear "2016" @default.
- W2520173345 type Work @default.
- W2520173345 sameAs 2520173345 @default.
- W2520173345 citedByCount "2" @default.
- W2520173345 countsByYear W25201733452019 @default.
- W2520173345 crossrefType "journal-article" @default.
- W2520173345 hasAuthorship W2520173345A5026740203 @default.
- W2520173345 hasAuthorship W2520173345A5082176880 @default.
- W2520173345 hasConcept C120770815 @default.
- W2520173345 hasConcept C126322002 @default.
- W2520173345 hasConcept C164705383 @default.
- W2520173345 hasConcept C2777099384 @default.
- W2520173345 hasConcept C2777321227 @default.
- W2520173345 hasConcept C2778198053 @default.
- W2520173345 hasConcept C2780972559 @default.
- W2520173345 hasConcept C2780994212 @default.
- W2520173345 hasConcept C519581460 @default.
- W2520173345 hasConcept C71924100 @default.
- W2520173345 hasConcept C78085059 @default.
- W2520173345 hasConceptScore W2520173345C120770815 @default.
- W2520173345 hasConceptScore W2520173345C126322002 @default.
- W2520173345 hasConceptScore W2520173345C164705383 @default.
- W2520173345 hasConceptScore W2520173345C2777099384 @default.
- W2520173345 hasConceptScore W2520173345C2777321227 @default.
- W2520173345 hasConceptScore W2520173345C2778198053 @default.
- W2520173345 hasConceptScore W2520173345C2780972559 @default.
- W2520173345 hasConceptScore W2520173345C2780994212 @default.
- W2520173345 hasConceptScore W2520173345C519581460 @default.
- W2520173345 hasConceptScore W2520173345C71924100 @default.
- W2520173345 hasConceptScore W2520173345C78085059 @default.
- W2520173345 hasLocation W25201733451 @default.
- W2520173345 hasLocation W25201733452 @default.
- W2520173345 hasOpenAccess W2520173345 @default.
- W2520173345 hasPrimaryLocation W25201733451 @default.
- W2520173345 hasRelatedWork W164205712 @default.
- W2520173345 hasRelatedWork W2000557719 @default.
- W2520173345 hasRelatedWork W2067292833 @default.
- W2520173345 hasRelatedWork W2091289701 @default.
- W2520173345 hasRelatedWork W2122993849 @default.
- W2520173345 hasRelatedWork W2168671610 @default.
- W2520173345 hasRelatedWork W2176863365 @default.
- W2520173345 hasRelatedWork W2277464475 @default.
- W2520173345 hasRelatedWork W2292856586 @default.
- W2520173345 hasRelatedWork W2400975872 @default.
- W2520173345 hasRelatedWork W2462116812 @default.
- W2520173345 hasRelatedWork W2503240356 @default.
- W2520173345 hasRelatedWork W2914437367 @default.
- W2520173345 hasRelatedWork W2973510595 @default.
- W2520173345 hasRelatedWork W2982034151 @default.
- W2520173345 hasRelatedWork W2982037107 @default.
- W2520173345 hasRelatedWork W3048068182 @default.
- W2520173345 hasRelatedWork W3096033968 @default.
- W2520173345 hasRelatedWork W3116808731 @default.
- W2520173345 hasRelatedWork W3195940087 @default.
- W2520173345 isParatext "false" @default.
- W2520173345 isRetracted "false" @default.
- W2520173345 magId "2520173345" @default.
- W2520173345 workType "article" @default.