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• W2520243180 abstract "1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-substituted-phenylpiperazine moiety was prepared and has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The biological activity of compound 3k as anti-inflammatory agent was further investigated both in vitro and in vivo. Notably, compound 3k exhibited the best anti-inflammatory activity among the eleven designed compounds with no toxicity, as determined by the ulcerogenic activity. Computational docking studies also showed that compound 3k has interaction with COX-2 key residues in the active site. Compound 3k maybe a new anti-inflammatory lead-candidate as powerful and novel non-ulcerogenic." @default.
• W2520243180 created "2016-09-23" @default.
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• W2520243180 date "2016-11-01" @default.
• W2520243180 modified "2023-09-25" @default.
• W2520243180 title "Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents" @default.
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• W2520243180 doi "https://doi.org/10.1016/j.bmc.2016.09.023" @default.
• W2520243180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27658794" @default.
• W2520243180 hasPublicationYear "2016" @default.
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