Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520248520> ?p ?o ?g. }
- W2520248520 endingPage "1607" @default.
- W2520248520 startingPage "1595" @default.
- W2520248520 abstract "Background/Aims: It is known that mesenchymal stem cells (MSCs) can have variable responses to hypoxic conditions and that hypoxia may specifically stimulate differentiation into osteogenic, chondrogenic, or adipogenic cells. Based on our previous study, we hypothesized that hypoxia may also induce MSC differentiation into cardiomyocytes and/or cells with comparable phenotypes. Methods: The differences in the proteomes were specifically investigated in bone marrow-derived rat MSCs (BM-rMSCs) under normoxic and hypoxic conditions using 2-DE combined with a MALDI-TOF-MS analysis and western blot analysis. In addition, genetic and/or proteomic interactions were assessed using a String network analysis. Results: Among the 35 markedly changed spots from a total of 393 matched spots, 24 were highly up-regulated and 11 were significantly down-regulated in hypoxic rMSCs based on a proteomic analysis. Although hypoxia failed to induce the direct differentiation of rMSCs into cardiomyocytes, several cardiomyocyte differentiation-related genes and proteins were significantly increased by hypoxic stress. Conclusion: We found that BM-rMSCs alter their expression of several cardiomyocyte differentiation-related genes and proteins under hypoxic conditions, and we examined the interactions between these genes and/or proteins, providing new insights for the applicability of MSCs preconditioned by hypoxic stimulation for use in cardiac diseases." @default.
- W2520248520 created "2016-09-23" @default.
- W2520248520 creator A5008336825 @default.
- W2520248520 creator A5036105363 @default.
- W2520248520 creator A5053535957 @default.
- W2520248520 creator A5056005181 @default.
- W2520248520 creator A5057141956 @default.
- W2520248520 creator A5062362792 @default.
- W2520248520 creator A5080250415 @default.
- W2520248520 creator A5082006124 @default.
- W2520248520 creator A5084473082 @default.
- W2520248520 creator A5085547301 @default.
- W2520248520 creator A5076623639 @default.
- W2520248520 date "2016-01-01" @default.
- W2520248520 modified "2023-10-10" @default.
- W2520248520 title "Alterations in Cardiomyocyte Differentiation-Related Proteins in Rat Mesenchymal Stem Cells Exposed to Hypoxia" @default.
- W2520248520 cites W1502442150 @default.
- W2520248520 cites W1548477536 @default.
- W2520248520 cites W1602684793 @default.
- W2520248520 cites W1966536689 @default.
- W2520248520 cites W1974207011 @default.
- W2520248520 cites W1974962865 @default.
- W2520248520 cites W1983324264 @default.
- W2520248520 cites W1987885331 @default.
- W2520248520 cites W1989546562 @default.
- W2520248520 cites W1990518016 @default.
- W2520248520 cites W1996526080 @default.
- W2520248520 cites W1998744127 @default.
- W2520248520 cites W2011904570 @default.
- W2520248520 cites W2014287951 @default.
- W2520248520 cites W2017088597 @default.
- W2520248520 cites W2034872754 @default.
- W2520248520 cites W2036452348 @default.
- W2520248520 cites W2043263890 @default.
- W2520248520 cites W2048550005 @default.
- W2520248520 cites W2056444297 @default.
- W2520248520 cites W2057597564 @default.
- W2520248520 cites W2066954473 @default.
- W2520248520 cites W2074121232 @default.
- W2520248520 cites W2080592158 @default.
- W2520248520 cites W2089771325 @default.
- W2520248520 cites W2091395040 @default.
- W2520248520 cites W2096173332 @default.
- W2520248520 cites W2098209017 @default.
- W2520248520 cites W2103111354 @default.
- W2520248520 cites W2104113751 @default.
- W2520248520 cites W2104474376 @default.
- W2520248520 cites W2110165642 @default.
- W2520248520 cites W2110980549 @default.
- W2520248520 cites W2121559647 @default.
- W2520248520 cites W2127913442 @default.
- W2520248520 cites W2149461114 @default.
- W2520248520 cites W2153949260 @default.
- W2520248520 cites W2158739674 @default.
- W2520248520 cites W2159999899 @default.
- W2520248520 cites W2161673104 @default.
- W2520248520 cites W2164511316 @default.
- W2520248520 cites W2167202160 @default.
- W2520248520 cites W2191284640 @default.
- W2520248520 cites W2254168793 @default.
- W2520248520 cites W2273877888 @default.
- W2520248520 cites W2305842675 @default.
- W2520248520 doi "https://doi.org/10.1159/000447861" @default.
- W2520248520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27627433" @default.
- W2520248520 hasPublicationYear "2016" @default.
- W2520248520 type Work @default.
- W2520248520 sameAs 2520248520 @default.
- W2520248520 citedByCount "12" @default.
- W2520248520 countsByYear W25202485202016 @default.
- W2520248520 countsByYear W25202485202017 @default.
- W2520248520 countsByYear W25202485202018 @default.
- W2520248520 countsByYear W25202485202019 @default.
- W2520248520 countsByYear W25202485202020 @default.
- W2520248520 countsByYear W25202485202021 @default.
- W2520248520 crossrefType "journal-article" @default.
- W2520248520 hasAuthorship W2520248520A5008336825 @default.
- W2520248520 hasAuthorship W2520248520A5036105363 @default.
- W2520248520 hasAuthorship W2520248520A5053535957 @default.
- W2520248520 hasAuthorship W2520248520A5056005181 @default.
- W2520248520 hasAuthorship W2520248520A5057141956 @default.
- W2520248520 hasAuthorship W2520248520A5062362792 @default.
- W2520248520 hasAuthorship W2520248520A5076623639 @default.
- W2520248520 hasAuthorship W2520248520A5080250415 @default.
- W2520248520 hasAuthorship W2520248520A5082006124 @default.
- W2520248520 hasAuthorship W2520248520A5084473082 @default.
- W2520248520 hasAuthorship W2520248520A5085547301 @default.
- W2520248520 hasBestOaLocation W25202485201 @default.
- W2520248520 hasConcept C104317684 @default.
- W2520248520 hasConcept C104397665 @default.
- W2520248520 hasConcept C122927707 @default.
- W2520248520 hasConcept C127716648 @default.
- W2520248520 hasConcept C148738053 @default.
- W2520248520 hasConcept C150194340 @default.
- W2520248520 hasConcept C153911025 @default.
- W2520248520 hasConcept C178790620 @default.
- W2520248520 hasConcept C185592680 @default.
- W2520248520 hasConcept C198826908 @default.
- W2520248520 hasConcept C2776415932 @default.