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- W2520248889 abstract "Over the past few decades, the interest in magnetizable nanocolloids has steadily increased as a result of the growing number of applications which can be designed both in the field of biotechnology and biomedicine. To improve the colloidal stability the particles have to be wrapped in a cushion of adsorbing molecules such as dextrans which are often used for the production of magnetic resonance imaging (MRI) agents. However, the dextran coating is vulnerable to aging and may induce alterations in the behavior and morphology of cells in culture. As a promising alternative we introduced in the late 1980’s so-called magnetoliposomes (MLs) [1]. These constructs consist of nanometer-sized magnetite (Fe3O4) cores covered with a bilayer of phospholipid molecules. The inner leaflet molecules are very strongly chemisorbed with their polar headgroup on the Fe3O4 surface, whereas those residing in the outer layer are more loosely physisorbed. Since phospholipids are components of all biological membranes, MLs can be considered as highly biocompatible, which is essential, for instance, for in vivo cell labeling [2]." @default.
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- W2520248889 date "2011-05-01" @default.
- W2520248889 modified "2023-09-23" @default.
- W2520248889 title "Magnetoliposomes open up new horizons as MRI contrast agents" @default.
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- W2520248889 hasPublicationYear "2011" @default.
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