FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520252432> ?p ?o ?g. }

• W2520252432 endingPage "150" @default.
• W2520252432 startingPage "144" @default.
• W2520252432 abstract "Human cytomegalovirus (HCMV) has been recognized as a cause of severe, sometimes life-threatening disease in congenitally infected newborns as well as in immunocompromised individuals. However, the molecular mechanisms of the host-virus interaction remain poorly understood. Here, we profiled the expression of mRNAs and long noncoding RNAs (lncRNAs) in THP-1 cells using the emerging RNA-seq to investigate the transcriptional changes during HCMV latent infection. At 4 days post HCMV infection, a total of 169,008,624 sequence reads and 180,616 transcripts were obtained, respectively. Of these transcripts, 1,354 noncoding genes and 12,952 protein-coding genes were observed in Refseq database. Differential gene expression analysis identified 2,153 differentially expressed genes (DEGs) between HCMV-infected and mock-infected THP-1 cells, including 1,098 up-regulated genes and 1,055 down-regulated genes. These regulated genes were involved in pathways of apoptosis, inflammatory response and cell cycle progression, all of which may be implicated in viral pathogenesis. In addition, 646 lncRNAs (208 known lncRNAs and 438 novel lncRNAs) were upregulated and 424 (140 known and 284 novel) were downregulated in infected THP-1 cells. These findings have provided a dynamic scenario of DE candidate genes and lncRNAs at the virus-host interface and clearly warrant further experimental investigation associated with HCMV infection." @default.
• W2520252432 created "2016-09-23" @default.
• W2520252432 creator A5009185395 @default.
• W2520252432 creator A5014346076 @default.
• W2520252432 creator A5026984704 @default.
• W2520252432 creator A5028309511 @default.
• W2520252432 creator A5044460309 @default.
• W2520252432 creator A5055338510 @default.
• W2520252432 date "2016-12-01" @default.
• W2520252432 modified "2023-10-17" @default.
• W2520252432 title "Transcriptome altered by latent human cytomegalovirus infection on THP-1 cells using RNA-seq" @default.
• W2520252432 cites W1536684667 @default.
• W2520252432 cites W1614146403 @default.
• W2520252432 cites W1623819487 @default.
• W2520252432 cites W1883977612 @default.
• W2520252432 cites W1963542053 @default.
• W2520252432 cites W1965316114 @default.
• W2520252432 cites W1976382352 @default.
• W2520252432 cites W1980343850 @default.
• W2520252432 cites W1981509058 @default.
• W2520252432 cites W1986823355 @default.
• W2520252432 cites W1991308016 @default.
• W2520252432 cites W2004008931 @default.
• W2520252432 cites W2007267903 @default.
• W2520252432 cites W2008715871 @default.
• W2520252432 cites W2009183786 @default.
• W2520252432 cites W2017317217 @default.
• W2520252432 cites W2021073494 @default.
• W2520252432 cites W2021911643 @default.
• W2520252432 cites W2030349605 @default.
• W2520252432 cites W2034023446 @default.
• W2520252432 cites W2034926804 @default.
• W2520252432 cites W2038353697 @default.
• W2520252432 cites W2048515474 @default.
• W2520252432 cites W2054248370 @default.
• W2520252432 cites W2058547013 @default.
• W2520252432 cites W2060961733 @default.
• W2520252432 cites W2061548680 @default.
• W2520252432 cites W2066125587 @default.
• W2520252432 cites W2066274736 @default.
• W2520252432 cites W2071756586 @default.
• W2520252432 cites W2072240314 @default.
• W2520252432 cites W2072521717 @default.
• W2520252432 cites W2074011532 @default.
• W2520252432 cites W2079377885 @default.
• W2520252432 cites W2081566793 @default.
• W2520252432 cites W2087377443 @default.
• W2520252432 cites W2091025707 @default.
• W2520252432 cites W2095188839 @default.
• W2520252432 cites W2097065948 @default.
• W2520252432 cites W2102597691 @default.
• W2520252432 cites W2102621085 @default.
• W2520252432 cites W2102740981 @default.
• W2520252432 cites W2108051165 @default.
• W2520252432 cites W2112682556 @default.
• W2520252432 cites W2114795453 @default.
• W2520252432 cites W2119627739 @default.
• W2520252432 cites W2121211805 @default.
• W2520252432 cites W2125813628 @default.
• W2520252432 cites W2131016694 @default.
• W2520252432 cites W2132869468 @default.
• W2520252432 cites W2137839234 @default.
• W2520252432 cites W2139319526 @default.
• W2520252432 cites W2145162535 @default.
• W2520252432 cites W2150048195 @default.
• W2520252432 cites W2154431984 @default.
• W2520252432 cites W2156967716 @default.
• W2520252432 cites W2157399331 @default.
• W2520252432 cites W2157861528 @default.
• W2520252432 cites W2158541290 @default.
• W2520252432 cites W2167381190 @default.
• W2520252432 cites W2335925695 @default.
• W2520252432 doi "https://doi.org/10.1016/j.gene.2016.09.014" @default.
• W2520252432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7126988" @default.
• W2520252432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27623506" @default.
• W2520252432 hasPublicationYear "2016" @default.
• W2520252432 type Work @default.
• W2520252432 sameAs 2520252432 @default.
• W2520252432 citedByCount "23" @default.
• W2520252432 countsByYear W25202524322017 @default.
• W2520252432 countsByYear W25202524322018 @default.
• W2520252432 countsByYear W25202524322019 @default.
• W2520252432 countsByYear W25202524322020 @default.
• W2520252432 countsByYear W25202524322021 @default.
• W2520252432 countsByYear W25202524322022 @default.
• W2520252432 countsByYear W25202524322023 @default.
• W2520252432 crossrefType "journal-article" @default.
• W2520252432 hasAuthorship W2520252432A5009185395 @default.
• W2520252432 hasAuthorship W2520252432A5014346076 @default.
• W2520252432 hasAuthorship W2520252432A5026984704 @default.
• W2520252432 hasAuthorship W2520252432A5028309511 @default.
• W2520252432 hasAuthorship W2520252432A5044460309 @default.
• W2520252432 hasAuthorship W2520252432A5055338510 @default.
• W2520252432 hasBestOaLocation W25202524321 @default.
• W2520252432 hasConcept C104317684 @default.
• W2520252432 hasConcept C107397762 @default.
• W2520252432 hasConcept C150194340 @default.
• W2520252432 hasConcept C159047783 @default.

• next