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• W2520333550 endingPage "2662" @default.
• W2520333550 startingPage "2647" @default.
• W2520333550 abstract "Aim: We wanted to assess the potency of a trifunctional nanoparticle (NP) that targeted and activated CD8 + dendritic cells (DC) and delivered an antigen to induce antitumor responses. Materials & methods: The DC targeting and activating properties of ferrous NPs conjugated with immunostimulatory CpG-oligonucleotides, anti-DEC205 antibody and ovalbumin (OVA) as a model antigen to induce antigen-specific T-cell responses and antitumor responses were analyzed. Results: OVA-loaded NP conjugated with immunostimulatory CpG-oligonucleotides and anti-DEC205 antibody efficiently targeted and activated CD8 + DC in vivo, and induced strong OVA-specific T-cell activation. Vaccination of B16/OVA tumor-burdened mice with this NP formulation resulted in tumor growth arrest. Conclusion: CD8 + DC-targeting trifunctional nanocarriers bear significant potential for antitumor immunotherapy." @default.
• W2520333550 created "2016-09-23" @default.
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• W2520333550 date "2016-10-01" @default.
• W2520333550 modified "2023-09-30" @default.
• W2520333550 title "Vaccination with trifunctional nanoparticles that address CD8⁺ dendritic cells inhibits growth of established melanoma" @default.
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• W2520333550 doi "https://doi.org/10.2217/nnm-2016-0174" @default.
• W2520333550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27628310" @default.
• W2520333550 hasPublicationYear "2016" @default.
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