FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2520346473> ?p ?o ?g. }

• W2520346473 abstract "Corneal endothelial transplantation has become the gold standard for the treatment of corneal endothelial dysfunctions, replacing full thickness transplantation, known as penetrating keratoplasty. Corneal endothelial transplantation has been described using two different techniques: Descemet's membrane endothelial keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK). Both are still performed worldwide.To compare the effectiveness and safety of Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for the treatment of corneal endothelial failure in people with Fuch's endothelial dystropy (FED) and pseudophakic bullous keratopathy (PBK).We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 7); MEDLINE Ovid; Embase Ovid; LILACS BIREME; the ISRCTN registry; ClinicalTrials.gov and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP). The date of the search was 11 August 2017.We included randomised controlled trials (RCTs) and non-randomised paired, contralateral-eye studies in any setting where DMEK was compared with DSAEK to treat people with corneal endothelial failure.Two review authors independently screened the search results, assessed trial quality and extracted data using the standard methodological procedures expected by Cochrane. Our primary outcome was best corrected visual acuity (BCVA) measured in logarithm of the Minimum Angle of Resolution (logMAR). Secondary outcomes were endothelial cell count, graft rejection, primary graft failure and graft dislocation. We graded the risk of bias of non-randomised studies (NRSs) using ROBINS-I.We did not identify any RCTs but found four non-randomised studies (NRSs) including 72 participants (144 eyes), who had received DSAEK in the first eye followed by DMEK in the fellow eye. All the studies included adult participants where there was evidence of FED and endothelial failure requiring a corneal transplant for the treatment of visual impairment. We did not find any studies that included PBK. The trials were published between 2011 and 2015, and we assessed them as high risk of bias due to potential unknown confounding factors since DSAEK preceded DMEK in all participants. Two studies reported results at 12 months, one at 6 months, and one between 6 and 24 months. At one year, using DMEK in cases of endothelial failure may result in better BCVA compared with DSAEK (mean difference (MD) -0.14, 95% confidence interval (CI) -0.18 to -0.10 logMAR, 4 studies, 140 eyes, low-certainty evidence). None of the participants had severe visual loss (BCVA of 1.0 logMAR or more; very low-certainty evidence). Regarding endothelial cell count data (4 studies, 134 eyes) it is hard to draw any conclusions since two studies suggested no difference and the other two reported that DMEK provides a higher cell density at one year (very low-certainty evidence). No primary graft failure and only one graft rejection were recorded over four studies (144 eyes) (very low-certainty evidence). The most common complications reported were graft dislocations, which were recorded in one or two out of 100 participants with DSAEK but were more common using DMEK, although this difference could not be precisely estimated (risk ratio (RR) 5.40, 95% CI 1.51 to 19.3; 4 studies, 144 eyes, very low-certainty evidence).This review included studies conducted on people with corneal endothelium failure due to FED for whom both DMEK and DSAEK can be considered, and found low-certainty evidence that DMEK provides some advantage in terms of final BCVA, at the cost of more graft dislocations needing 're-bubbling' (very low-certainty of evidence)." @default.
• W2520346473 created "2016-09-23" @default.
• W2520346473 creator A5001982732 @default.
• W2520346473 creator A5015954067 @default.
• W2520346473 creator A5037763892 @default.
• W2520346473 creator A5052326232 @default.
• W2520346473 date "2018-06-25" @default.
• W2520346473 modified "2023-10-14" @default.
• W2520346473 title "Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure" @default.
• W2520346473 cites W105835818 @default.
• W2520346473 cites W114296581 @default.
• W2520346473 cites W1513498127 @default.
• W2520346473 cites W1755781740 @default.
• W2520346473 cites W1782000991 @default.
• W2520346473 cites W184641614 @default.
• W2520346473 cites W1864469836 @default.
• W2520346473 cites W1964070387 @default.
• W2520346473 cites W1970391673 @default.
• W2520346473 cites W1975031191 @default.
• W2520346473 cites W1981569689 @default.
• W2520346473 cites W1984943382 @default.
• W2520346473 cites W1994207755 @default.
• W2520346473 cites W1996050214 @default.
• W2520346473 cites W1997505481 @default.
• W2520346473 cites W2000452043 @default.
• W2520346473 cites W2004020040 @default.
• W2520346473 cites W2011254911 @default.
• W2520346473 cites W2014986850 @default.
• W2520346473 cites W2017178440 @default.
• W2520346473 cites W2017758930 @default.
• W2520346473 cites W2032456602 @default.
• W2520346473 cites W2033709694 @default.
• W2520346473 cites W2034089242 @default.
• W2520346473 cites W2039637636 @default.
• W2520346473 cites W2041996108 @default.
• W2520346473 cites W2047205175 @default.
• W2520346473 cites W2051052258 @default.
• W2520346473 cites W2057682409 @default.
• W2520346473 cites W2080232413 @default.
• W2520346473 cites W2084631349 @default.
• W2520346473 cites W2091537278 @default.
• W2520346473 cites W2102250286 @default.
• W2520346473 cites W2108455165 @default.
• W2520346473 cites W2125435699 @default.
• W2520346473 cites W2139297716 @default.
• W2520346473 cites W2143359043 @default.
• W2520346473 cites W2158712293 @default.
• W2520346473 cites W2159920218 @default.
• W2520346473 cites W2160458920 @default.
• W2520346473 cites W2223693598 @default.
• W2520346473 cites W2260167907 @default.
• W2520346473 cites W2313327985 @default.
• W2520346473 cites W2318338841 @default.
• W2520346473 cites W2323657713 @default.
• W2520346473 cites W2331696497 @default.
• W2520346473 cites W2408350635 @default.
• W2520346473 cites W2463630237 @default.
• W2520346473 cites W2498974848 @default.
• W2520346473 cites W2520346473 @default.
• W2520346473 cites W2525893411 @default.
• W2520346473 cites W2531269403 @default.
• W2520346473 cites W25377179 @default.
• W2520346473 cites W2559572751 @default.
• W2520346473 cites W2595419835 @default.
• W2520346473 cites W2607293493 @default.
• W2520346473 cites W2736315661 @default.
• W2520346473 cites W2749345275 @default.
• W2520346473 cites W2792308249 @default.
• W2520346473 cites W3183398458 @default.
• W2520346473 cites W4252202099 @default.
• W2520346473 cites W95707997 @default.
• W2520346473 doi "https://doi.org/10.1002/14651858.cd012097.pub2" @default.
• W2520346473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6513431" @default.
• W2520346473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29940078" @default.
• W2520346473 hasPublicationYear "2018" @default.
• W2520346473 type Work @default.
• W2520346473 sameAs 2520346473 @default.
• W2520346473 citedByCount "67" @default.
• W2520346473 countsByYear W25203464732018 @default.
• W2520346473 countsByYear W25203464732019 @default.
• W2520346473 countsByYear W25203464732020 @default.
• W2520346473 countsByYear W25203464732021 @default.
• W2520346473 countsByYear W25203464732022 @default.
• W2520346473 countsByYear W25203464732023 @default.
• W2520346473 crossrefType "journal-article" @default.
• W2520346473 hasAuthorship W2520346473A5001982732 @default.
• W2520346473 hasAuthorship W2520346473A5015954067 @default.
• W2520346473 hasAuthorship W2520346473A5037763892 @default.
• W2520346473 hasAuthorship W2520346473A5052326232 @default.
• W2520346473 hasBestOaLocation W25203464732 @default.
• W2520346473 hasConcept C118487528 @default.
• W2520346473 hasConcept C126322002 @default.
• W2520346473 hasConcept C141071460 @default.
• W2520346473 hasConcept C168563851 @default.
• W2520346473 hasConcept C2776882836 @default.
• W2520346473 hasConcept C2778257484 @default.
• W2520346473 hasConcept C2780686511 @default.
• W2520346473 hasConcept C3019694093 @default.
• W2520346473 hasConcept C535046627 @default.
• W2520346473 hasConcept C71924100 @default.

• next