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- W252034807 abstract "The tumor suppressor p53 is a major regulator of genes important for cell cycle arrest, senescence, apoptosis, and innate immunity, and has recently been implicated in retinal aging. In this study we sought to identify the genetic networks that regulate p53 function in the retina using quantitative trait locus (QTL) analysis. First we examined age-associated changes in the activation and expression levels of p53; known p53 target proteins and markers of innate immune system activation in primary retinal pigment epithelial (RPE) cells that were harvested from young and aged human donors. We observed increased expression of p53, activated caspase-1, CDKN1A, CDKN2A (p16INK4a), TLR4, and IFNα in aged primary RPE cell lines. We used the Hamilton Eye Institute (HEI) retinal dataset ( www.genenetwork.org ) to identify genomic loci that modulate expression of genes in the p53 pathway in recombinant inbred BXD mouse strains using a QTL systems biology-based approach. We identified a significant trans-QTL on chromosome 1 (region 172-177 Mb) that regulates the expression of Cdkn1a. Many of the genes in this QTL locus are involved in innate immune responses, including Fc receptors, interferon-inducible family genes, and formin 2. Importantly, we found an age-related increase in FCGR3A and FMN2 and a decrease in IFI16 levels in RPE cultures. There is a complex multigenic innate immunity locus that controls expression of genes in the p53 pathway in the RPE, which may play an important role in modulating age-related changes in the retina." @default.
- W252034807 created "2016-06-24" @default.
- W252034807 creator A5073983843 @default.
- W252034807 creator A5090611926 @default.
- W252034807 creator A5091627951 @default.
- W252034807 date "2015-05-12" @default.
- W252034807 modified "2023-09-26" @default.
- W252034807 title "Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium" @default.
- W252034807 cites W121889566 @default.
- W252034807 cites W1519633296 @default.
- W252034807 cites W1599235209 @default.
- W252034807 cites W1641067856 @default.
- W252034807 cites W1671931635 @default.
- W252034807 cites W1785576758 @default.
- W252034807 cites W1852412583 @default.
- W252034807 cites W1927742265 @default.
- W252034807 cites W1938625303 @default.
- W252034807 cites W1966318341 @default.
- W252034807 cites W1968298081 @default.
- W252034807 cites W1968884620 @default.
- W252034807 cites W1971349333 @default.
- W252034807 cites W1973723400 @default.
- W252034807 cites W1974273434 @default.
- W252034807 cites W1977294643 @default.
- W252034807 cites W1984036332 @default.
- W252034807 cites W1988410112 @default.
- W252034807 cites W1990588070 @default.
- W252034807 cites W1992994645 @default.
- W252034807 cites W1996470116 @default.
- W252034807 cites W1997028288 @default.
- W252034807 cites W2001468580 @default.
- W252034807 cites W2001692097 @default.
- W252034807 cites W2007151442 @default.
- W252034807 cites W2007665513 @default.
- W252034807 cites W2009306482 @default.
- W252034807 cites W2009703979 @default.
- W252034807 cites W2010417927 @default.
- W252034807 cites W2012447031 @default.
- W252034807 cites W2012583411 @default.
- W252034807 cites W2013721931 @default.
- W252034807 cites W2013730358 @default.
- W252034807 cites W2014481298 @default.
- W252034807 cites W2014871980 @default.
- W252034807 cites W2016159338 @default.
- W252034807 cites W2019362945 @default.
- W252034807 cites W2021521022 @default.
- W252034807 cites W2026677505 @default.
- W252034807 cites W2027372492 @default.
- W252034807 cites W2027659803 @default.
- W252034807 cites W2028666164 @default.
- W252034807 cites W2034060753 @default.
- W252034807 cites W2034080811 @default.
- W252034807 cites W2036812273 @default.
- W252034807 cites W2038851979 @default.
- W252034807 cites W2040310709 @default.
- W252034807 cites W2044567576 @default.
- W252034807 cites W2046735295 @default.
- W252034807 cites W2050089738 @default.
- W252034807 cites W2058124698 @default.
- W252034807 cites W2062000891 @default.
- W252034807 cites W2062641747 @default.
- W252034807 cites W2063974504 @default.
- W252034807 cites W2064625769 @default.
- W252034807 cites W2065206527 @default.
- W252034807 cites W2065870221 @default.
- W252034807 cites W2066218351 @default.
- W252034807 cites W2067290518 @default.
- W252034807 cites W2068348383 @default.
- W252034807 cites W2071776213 @default.
- W252034807 cites W2075225148 @default.
- W252034807 cites W2075727700 @default.
- W252034807 cites W2075901113 @default.
- W252034807 cites W2076017150 @default.
- W252034807 cites W2076700294 @default.
- W252034807 cites W2077203470 @default.
- W252034807 cites W2077671923 @default.
- W252034807 cites W2077672962 @default.
- W252034807 cites W2084371070 @default.
- W252034807 cites W2085197755 @default.
- W252034807 cites W2086914199 @default.
- W252034807 cites W2089001509 @default.
- W252034807 cites W2093055679 @default.
- W252034807 cites W2094805113 @default.
- W252034807 cites W2095277233 @default.
- W252034807 cites W2096107242 @default.
- W252034807 cites W2109623522 @default.
- W252034807 cites W2113179909 @default.
- W252034807 cites W2113718250 @default.
- W252034807 cites W2114994536 @default.
- W252034807 cites W2116342473 @default.
- W252034807 cites W2119075351 @default.
- W252034807 cites W2122510983 @default.
- W252034807 cites W2125619707 @default.
- W252034807 cites W2128647012 @default.
- W252034807 cites W2131078803 @default.
- W252034807 cites W2133959309 @default.
- W252034807 cites W2138657695 @default.
- W252034807 cites W2144309235 @default.